{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:10Z","timestamp":1745468710243,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy (OBX) causes dysfunction in spermatogenesis as a result of Onuf\u2019s nucleus damage. Methods: Twenty-eight male rats were divided into three groups: six as the control (G-1; n = 6), six as the only frontal burr hole applied animals SHAM (G-2; n = 6), and 16 as the study group (G-3; n = 16) in which OBX was performed. The animals were followed for 2 months. After the decapitation of the animals, olfactory bulb (OB) volumes (mm3), the neuron density of the Onuf\u2019s nucleus (n\/mm3), and sperm density (n\/mm3) were estimated stereologically and analyzed. Results: OB volumes (mm3), degenerated neuron density of Onuf\u2019s nucleus (n\/mm3), and sperm numbers of control, SHAM, and study groups were estimated as: 4 \u00b1 0.5; 6 \u00b1 2 and 103.245 \u00b1 10.841 in G-1; 3.5 \u00b1 0.7; 14 \u00b1 4 and 96.891 \u00b1 9.569 in G-2; and 1.3 \u00b1 0.3; 91 \u00b1 17 and 73.561 \u00b1 6.324 in G-3. The statistical results of degenerated neuron density of Onuf\u2019s nucleus and sperm numbers between groups are p &amp;lt; 0.005 for G-1\/G-2; p &amp;lt; 0.0005 for G-2\/G-3; and p &amp;lt; 0.00001 for G-1\/G-3. Discussion: This study first time indicates that Onuf\u2019s nucleus degeneration secondary to OBX seems to be responsible for reduced sperm numbers. <\/jats:p>","DOI":"10.1159\/000531962","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T06:58:00Z","timestamp":1691477880000},"page":"1051-1058","source":"Crossref","is-referenced-by-count":1,"title":["From Nose to Lumbar Spinal Cord \u2013 Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf\u2019s Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome"],"prefix":"10.1159","volume":"113","author":[{"given":"Coskun","family":"Yolas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayhan","family":"Kanat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mete","family":"Zeynal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet H.","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet K.","family":"Karadag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman 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