{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T04:45:40Z","timestamp":1773463540782,"version":"3.50.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Trimethoprim-sulfamethoxazole (TMP-SMX) is an important antibiotic, with the most compelling indications for Pneumocystis jirovecii pneumonia prophylaxis and methicillin-resistant Staphylococcus aureus treatment. Previous adverse reactions (AR) to TMP-SMX may limit the usability of TMP-SMX. Electronic medical record (EMR) of AR for other antibiotics has previously been shown to be inaccurate; however, the extent to which this occurs for TMP-SMX is unknown. Methods: A multi-centre retrospective observational study was conducted for consecutive inpatient admissions over a 2.5-year period commencing 2020. Adverse reactions to TMP-SMX recorded in the EMR were collected and reviewed by two independent medical officers using pre-defined expert criteria for the classification of allergies and intolerances. Results: TMP-SMX AR were present in the EMR of 759 individuals (prevalence 0.6%). The majority were labelled as allergy (725, 95.5%) rather than intolerance (34, 4.5%). Most common AR were rash, vomiting, and swelling. When classified against the gold-standard expert criteria, there were 437 allergies (57.6%) and 159 intolerances (21.0%). Overall, the number of incorrect EMR AR labels was 133\/759 (17.5%). Both medical and surgical specialties had significant numbers of patients with TMP-SMX AR labels and incorrectly classified EMR AR labels. Conclusion: TMP-SMX AR labels affect inpatients admitted under multiple specialty units. The user-entered categorization as allergy or intolerance labels in EMRs are frequently used incorrectly. These incorrect labels may inappropriately contraindicate the use of TMP-SMX, and formal evaluation of TMP-SMX ARs with immunological assessment and relabelling where appropriate may increase the use of this agent. <\/jats:p>","DOI":"10.1159\/000531975","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"1225-1229","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Trimethoprim-Sulfamethoxazole Adverse Reaction Mislabelling in Australia"],"prefix":"10.1159","volume":"184","author":[{"given":"Lydia","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Inglis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr","family":"Shakib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Yuson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111152"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13562"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0289-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13558"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.01.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000526424"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.07.048"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.2022118"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd005646.pub2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086\/516995"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15209"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.550"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.05.017"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403789"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.11.035"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002863"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-018-0136-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2021.104611"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/184\/12\/1225\/4061289\/000531975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/184\/12\/1225\/4061289\/000531975.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:31:16Z","timestamp":1745422276000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,14]]},"published-print":{"date-parts":[[2023,12,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000531975","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24056790","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}