{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:42Z","timestamp":1745468682108,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Transcatheter aortic valve implantation (TAVI) is associated with a high incidence of new silent brain infarcts (SBIs) on postprocedural neuroimaging. A venous blood sample reflecting neuronal damage following TAVI could help identify patients with potential SBIs. We aimed to investigate if a biochemical marker of neuronal injury, neurofilament light chain (NFL), is elevated after TAVI. Methods: In this observational study, NFL was measured in plasma from 31 patients before and after TAVI. Multivariable regression analysis was performed to investigate any effect of clinical- and procedure-related factors on differences in NFL levels before and after TAVI. Results: Samples were collected 41 (14\u201381) days before and 44 (35\u201359) days after TAVI, median (interquartile range). Median age was 81 (77\u201384) years, and 35% were female. No patient had any overt procedure-related neurological complications. The geometric mean (95% confidence interval) of the NFL concentration was 30 (25\u201336) pg\/mL before TAVI and 48 (39\u201361) pg\/mL, after TAVI, p &amp;lt;0.001. None of the included variables in the multiple linear regression model were statistically significantly associated with the difference in levels before and after TAVI. Conclusions: NFL levels in plasma were higher after TAVI as compared with levels before, with a mean increase of 60% (18 pg\/mL). Further studies including neuroimaging and cognitive outcomes are needed to understand the potential value of measuring NFL in relation to TAVI. <\/jats:p>","DOI":"10.1159\/000532041","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T06:58:00Z","timestamp":1691477880000},"page":"478-484","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Neurofilament Light Chain Is Elevated after Transcatheter Aortic Valve Implantation"],"prefix":"10.1159","volume":"148","author":[{"given":"Karl","family":"Sj\u00f6lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Christersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Lindb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signild","family":"\u00c5sberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Burman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2172"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.855866"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.026"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001091"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010920"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018309"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006282"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518765666"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025910"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.05.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10302"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-21-00951"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022066"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3061"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204961"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191165"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02563.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I11A198"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.10.022"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.12.042"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.841898"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crd\/article-pdf\/148\/5\/478\/4025808\/000532041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/148\/5\/478\/4025808\/000532041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:32:11Z","timestamp":1745422331000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000532041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,2]]},"published-print":{"date-parts":[[2023,10,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000532041","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2023]]}}}