{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:05:41Z","timestamp":1764997541693,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Tuberous sclerosis (TS) is a rare autosomal dominant genetic multisystem disease caused by mutations in either the &lt;i&gt;TSC1&lt;\/i&gt; or &lt;i&gt;TSC2&lt;\/i&gt; gene and results in the growth of non-cancerous masses in several organs. Diffuse large B-cell lymphoma (DLBCL) is the predominant non-Hodgkin lymphoma in adolescents and young adults. Metronomic chemotherapy (mCHEMO) can be defined as the frequent, regular administration of drug doses able to maintain a low, but active, range of concentrations of chemotherapeutic drugs during prolonged periods of time. We present the case of a young woman with severe TS who developed DLBCL. She was treated consecutively with the mCHEMO schedule R-DEVEC (prednisone, vinorelbine, etoposide, cyclophosphamide, plus rituximab) and then ibrutinib, achieving an impressive long-lasting complete remission. In conclusion, alternative treatments could be necessary when comorbidities are present in patients, and mCHEMO can be a potential successful therapeutic approach in frail subjects. <\/jats:p>","DOI":"10.1159\/000533236","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T06:58:00Z","timestamp":1691477880000},"page":"40-44","source":"Crossref","is-referenced-by-count":4,"title":["Complete Remission of a Diffuse Large B-Cell Lymphoma in a Young Patient, with Severe Tuberous Sclerosis, Treated with Metronomic Chemotherapy and Ibrutinib: A Case Report"],"prefix":"10.1159","volume":"69","author":[{"given":"Marta","family":"Banchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Lanzolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Di Napoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Bandini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Christina","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37754.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61279-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14074"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017008748"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.227272"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798589"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-671362"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.25"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.64"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.06.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.10.018"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216254"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15039"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-019-00769-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-020-04172-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11237162"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214122"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3884"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.213"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02403"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ncb839"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-722900"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/che\/article-pdf\/69\/1\/40\/4172706\/000533236.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/che\/article-pdf\/69\/1\/40\/4172706\/000533236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:34:09Z","timestamp":1745422449000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,26]]},"published-print":{"date-parts":[[2024,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000533236","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2023,8,7]]}}}