{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:14:40Z","timestamp":1786364080273,"version":"build-2736575974"},"reference-count":20,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Acute exacerbation (AE) occasionally develops in the course of fibrotic hypersensitivity pneumonitis (HP). Objective: The aim of the study was to compare AE of fibrotic HP with that of idiopathic pulmonary fibrosis (IPF). Methods: Consecutive patients with pathologically confirmed fibrotic HP and IPF diagnosed based on a multidisciplinary discussion were included in the analysis. AE in patients with fibrotic HP and IPF was evaluated retrospectively. Results: This study included 309 and 160 patients with fibrotic HP and IPF, respectively. Their 50% survival times were 96.1 and 78.0 months, respectively (hazard ratio [HR]: 0.54 [95% confidence interval, CI: 0.36\u20130.77], log-rank test; p &amp;lt; 0.001). Notably, the cumulative AE rates of fibrotic HP were 3% at 1 year and 10% at 3 years. Moreover, the corresponding rates of IPF were 8% at 1 year and 20% at 3 years (HR: 0.66 [95% CI: 0.45\u20130.93], log-rank test; p = 0.034). The 90-day survival rates from the AE onset of fibrotic HP and IPF were 75% and 64%, respectively (HR: 0.51 [95% CI: 0.31\u20130.83], log-rank test; p = 0.006). The respiratory function test on the physiological criteria of progressive pulmonary fibrosis (PPF) was a predictor of AE in fibrotic HP. However, the high-resolution CT (HRCT) changes in the criteria of PPF were not. Nevertheless, both the physiological and radiological criteria of PPF were a predictor of AE of IPF. Conclusion: AE of fibrotic HP has a lesser prognostic effect than that of IPF. HRCT criteria for PPF were not a risk factor for AE in patients with fibrotic HP. <\/jats:p>","DOI":"10.1159\/000533312","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T21:00:41Z","timestamp":1695330041000},"page":"803-812","source":"Crossref","is-referenced-by-count":11,"title":["Acute Exacerbation and Proposed Criteria for Progressive Pulmonary Fibrosis in Patients with Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis"],"prefix":"10.1159","volume":"102","author":[{"given":"Ryo","family":"Okuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiko","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Iwasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01748-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-2032ST"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.36141\/svdld.v36i1.7117"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.09.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13682"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01978-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0866"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159709"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07469-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4936-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2685"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13752"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000528576"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.06.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193608"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02465-2018"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/res\/article-pdf\/doi\/10.1159\/000533312\/3991670\/000533312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/res\/article-pdf\/doi\/10.1159\/000533312\/3991670\/000533312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:34:55Z","timestamp":1745422495000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,21]]},"published-print":{"date-parts":[[2023,9,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000533312","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}