{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:43:41Z","timestamp":1780375421968,"version":"3.54.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Hazelnuts are a leading trigger of food allergy. To date, several molecular components of hazelnut are available for component-resolved diagnosis. However, little is known about how simultaneous sensitization to multiple allergens affects the severity of the hazelnut-induced reaction. In a previous study, our group demonstrated a lower risk of systemic reactions to peach in patients sensitized to both <i>Pru p 3<\/i> and <i>Pru p 1<\/i> than in the patient monosensitized to peach LTP. We aimed to assess whether this was also true in hazelnut allergy in a cohort of adult patients. <b><i>Methods:<\/i><\/b> Patients were selected based on a history of symptoms such as urticaria, vomiting, diarrhea, asthma, and anaphylaxis indicative of hazelnut IgE-mediated food allergy and graded according to a clinical severity scale. For all patients, specific IgE was determined for <i>Cor a 1<\/i> and <i>Cor a 8<\/i> and, for most patients, also <i>Cor a 9<\/i>. Patients were offered an oral food challenge in open format (OFC) with a cocoa-based roasted hazelnut spread on a voluntary basis in order to prescribe an appropriate diet. <b><i>Results:<\/i><\/b> A total of two hundred and fourteen patients were recruited. Among these, 43 patients were monosensitized to <i>Cor a 8<\/i>. One hundred and seventy-one patients were sensitized to <i>Cor a 1<\/i> (79.9%), and, among them, 48\/171 (28.1%) were also <i>Cor a 8<\/i> positive. <i>Cor a 9<\/i> was evaluated in 124\/214 patients, testing positive in 21\/124 (16.9%). Patients monosensitized to <i>Cor a 8<\/i> experienced systemic reactions more frequently than those sensitized to <i>Cor a 1<\/i> \u00b1 <i>Cor a 8<\/i> (<i>p<\/i> &lt; 0.00001), with significantly more severe reactions (<i>p<\/i> &lt; 0.0005) and testing more frequently positive at OFC (<i>p<\/i> &lt; 0.0001). Regarding <i>Cor a<\/i> 9, the sensitized patients were significantly younger (<i>p<\/i> = 0.0013) and showed reactions of similar severity to patients who tested <i>Cor a 9<\/i> negative, and these reactions were milder than in patients monosensitized only to <i>Cor a<\/i> 8. <b><i>Discussion\/Conclusion:<\/i><\/b> Sensitization to <i>Cor a 1<\/i> seems to protect from the development of the severe systemic reactions induced by <i>Cor a<\/i> 8 sensitization, <i>Cor a 9<\/i> does not influence the severity of symptoms in adult patients. The OFC with roasted hazelnut may help in dietary guidance. <\/jats:p>","DOI":"10.1159\/000533313","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T22:00:30Z","timestamp":1702072830000},"page":"237-246","source":"Crossref","is-referenced-by-count":9,"title":["The Severity and Frequency of Systemic Reactions to Hazelnut Are Significantly Higher in Hazelnut Allergic Patients Monosensitized to <i>Cor a 8<\/i> than in Patients Polysensitized to <i>Cor a 1<\/i>, <i>Cor a 8<\/i>, and <i>Cor a 9<\/i>"],"prefix":"10.1159","volume":"185","author":[{"given":"Elide Anna","family":"Pastorello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Scibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-361X","authenticated-orcid":false,"given":"Carlo Maria","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Michelina","family":"Losappio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Nichelatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gloria","family":"Aversano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Farioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,12,8]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/3\/237\/4174603\/000533313.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/3\/237\/4174603\/000533313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:34:56Z","timestamp":1745422496000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,1]]},"published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000533313","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]}}}