{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:54Z","timestamp":1745468694122,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Colorectal cancer (CRC) is the third leading cause of mortality worldwide. The Food and Drug Administration recently designated pembrolizumab, an immune checkpoint inhibitor (ICI) against a programmed death-1 receptor, as a breakthrough drug for the treatment of patients with mCRC whose tumors have deficient mismatch-repair gene expression (as evidenced by microsatellite instability-high) and patients with solid tumors with a high tumor mutational burden with \u226510 mutations\/megabase. We present a patient with metastatic CRC having renal and adrenal gland metastases. Comprehensive molecular profiling performed on a site of metastatic CRC in the kidney revealed multiple genomic alterations characteristic of CRC and rare chromosome 9p24.1 amplification, resulting in a co-amplification of the &lt;i&gt;PDL1, PDL2&lt;\/i&gt;, and &lt;i&gt;JAK2&lt;\/i&gt; genes. Although this genomic alteration may predict the response to ICI, the lack of pembrolizumab prevented the patient from receiving targeted treatment and succumbing to the disease. <\/jats:p>","DOI":"10.1159\/000533377","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:07:23Z","timestamp":1697058443000},"page":"803-810","source":"Crossref","is-referenced-by-count":2,"title":["A Chromosome 9p24.1 Amplification in Colorectal Cancer with Metastases to the Kidney and Adrenal Gland: A Case Report"],"prefix":"10.1159","volume":"16","author":[{"given":"Ana","family":"Paric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Karan-Krizanac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Saric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semir","family":"Vranic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2016.008698"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2007.12.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2004.00971.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/707154"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-019-0611-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13194"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.632221"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12072"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1758835920936932"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103596"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03349-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.6027"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197907000-00013"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(80)80100-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831001)52:7%3c1317::aid-cncr2820520731%3e3.0.co;2-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1385\/IJGC:34:2-3:073"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.46.01.11"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0654"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1353-y"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3271"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1200\/PO.17.00252"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1701"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.11818"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1411087"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22365"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042320-034052"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/803\/4086230\/000533377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/803\/4086230\/000533377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:01Z","timestamp":1745422561000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000533377","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24015516","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2023,9,4]]}}}