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Karger AG","issue":"12","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: The aim of the study was to evaluate the perioperative risks and outcomes of ultra-radical surgery in patients with extensive metastatic ovarian growing teratoma syndrome (GTS). Methods: We conducted a retrospective study of patients with extensive metastatic ovarian GTS treated in our hospital between 2000 and 2022. Patients\u2019 clinical characteristics, surgical treatment, and outcomes were evaluated. Results: Overall, 13 patients were identified, and the median age at diagnosis of ovarian immature teratoma (IT) was 24 years (range: 5\u201337). The median interval between IT diagnosis and presenting GTS was 8 months (range: 2\u201360), with a median surgery delay of 5 months (range: 3\u2013300). Peritoneum and liver were the most commonly affected sites (100%), followed by bowel (12 patients, 92.3%), diaphragm (12 patients, 92.3%), adnexa (9 patients, 69.2%), omentum (8 patients, 61.5%), uterus (7 patients, 53.8%), in the descending order. The mean operation time was 316 min (range: 180\u2013625), and the mean blood loss volume was 992 mL (range: 200\u20135,000). Peritoneal metastasectomy (13 patients, 100%), diaphragmatic metastasectomy (12 patients, 92.3%), metastasis removal from the bowel (8 patients, 61.5%), partial hepatectomy (4 patients, 30.8%), bowel excision and anastomosis (1 patient, 7.7%) were also applied to achieve optimal debulking. R0 was achieved in 9 (69.2%) patients. A high rate of intraoperative blood transfusion (8 patients, 61.5%) and admission to the intensive care unit (9 patients, 69.2%) were observed, and the median postoperative hospitalization time was 8 days (range: 4\u201322). After a median follow-up of 3.3 years, 9 patients were free of disease, and 4 were alive with stable residual diseases. Conclusion: The survival outcomes in extensive metastatic ovarian GTS were satisfactory after ultra-radical surgery, while a proper therapeutic plan should be established due to the high perioperative risks. <\/jats:p>","DOI":"10.1159\/000533411","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T21:01:27Z","timestamp":1691614887000},"page":"773-781","source":"Crossref","is-referenced-by-count":0,"title":["Significance of Ultra-Radical Surgery in Extensive Metastatic Ovarian Growing Teratoma Syndrome"],"prefix":"10.1159","volume":"101","author":[{"given":"Sijian","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rundong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000216004.22588.ce"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.10.024"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8%3c1629::aid-cncr2820500828%3e3.0.co;2-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000751"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.52910"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00651-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4608-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000231686.94924.41"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.11.086"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12466"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.08.021"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181afde41"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.06.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.10.024"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29090501"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000073"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9260(05)80570-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.8998"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08989-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-0883-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12084"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/doi\/10.1159\/000533411\/4055808\/000533411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/doi\/10.1159\/000533411\/4055808\/000533411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:25Z","timestamp":1745422585000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000533411","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23909529","asserted-by":"subject"}]},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2023]]}}}