{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:40:31Z","timestamp":1788950431571,"version":"build-2803163510"},"reference-count":26,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Influenza virus causes significant global annual morbidity and mortality. Thrombocytopenia is recognized as a poor prognostic factor in sepsis and is associated with mortality, while lymphopenia has been established as a poor prognostic factor in other viral infections. We aimed to assess the incidence of thrombocytopenia and lymphopenia in seasonal influenza and their effect on clinical outcomes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This single-center, retrospective, cohort study included consecutive adult patients, hospitalized in Rabin Medical Center between October 2017 and April 2018, with laboratory-confirmed influenza. Patients were grouped according to blood counts on admission: (1) thrombocytopenia (&amp;lt;150 K\/mL), (2) lymphopenia (&amp;lt;0.5 K\/mL), and (3) both thrombocytopenia and lymphopenia. Patients without thrombocytopenia and lymphopenia were designated as controls. The primary outcome was 30-day all-cause mortality. Risk factors were identified by univariable and multivariable analyses, using logistic regression and reported as odds ratios (ORs) and 95% confidence intervals (CIs). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 625 patients were included, 112 (18%) had thrombocytopenia, 98 (15.6%) had lymphopenia, and 107 (17%) had both. The crude 30-day all-cause mortality was 7.6% (48\/625). Mortality rates were 7.1% (8\/112) for the thrombocytopenia group, 11.2% (11\/98) for the lymphopenia group, and 14.9% (16\/107) for patients with both versus 4.2% (13\/308) in the control (&lt;i&gt;p&lt;\/i&gt; = 0.000 for all). In a multivariable regression model, significant thrombocytopenia (&amp;lt;100 K\/\u03bcL) [OR 5.07 (95% CI 1.5\u201316.2)], age [OR 1.07 (95% CI 1.02\u20131.11)], time to oseltamivir [OR 1.006 (95% CI 1.002\u20131.11)], and significant respiratory support [OR 8.85 (3.4\u201322.6)] were associated with 30-day all-cause mortality. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Patients hospitalized with seasonal influenza and thrombocytopenia &amp;lt;100 K\/mL on admission, have an increased 30-day all-cause mortality. <\/jats:p>","DOI":"10.1159\/000533466","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T21:01:27Z","timestamp":1691614887000},"page":"481-489","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Thrombocytopenia and Lymphopenia on Mortality in Patients Infected with Influenza Virus: A Retrospective Cohort Study"],"prefix":"10.1159","volume":"146","author":[{"given":"Adi","family":"Sherban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragda","family":"Hussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter-Gvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Atamna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Bishara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ben Tikva Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1000449"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2011.11.020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/cc8044"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1425"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02204"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25421"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.ncc3-00"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.37.7.4085"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2608-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12346"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.17.194514"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200208000-00015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1243"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001520"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2013.13788"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26833"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002685"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0474-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0223-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921020-00003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697930"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg007"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001640"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/481\/4118428\/000533466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/481\/4118428\/000533466.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:54Z","timestamp":1745422614000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,22]]},"published-print":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000533466","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23909547","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}