{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:01Z","timestamp":1745468701292,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Ovarian metastasis of colorectal cancer is known to have a poor prognosis. This study aimed to elucidate the characteristics of patients who underwent oophorectomy for ovarian metastasis from colorectal cancer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This retrospective study included 16 patients who underwent oophorectomy for colorectal cancer metastasis to the ovary from January 2004 to December 2017. Improvement in patient\u2019s symptoms and pre- and postoperative changes in various nutritional and inflammatory indicators were assessed. Survival analysis and identification of prognostic factors were conducted with a median follow-up of 40.7 (5\u2013109) months. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 16 patients, 12 had (75%) synchronous and 4 (25%) had metachronous metastasis. Fourteen patients were symptomatic but symptoms resolved postoperatively. Thirteen patients (81.3%) had ascites and 5 (31.3%) had pleural effusion on preoperative computed tomography that disappeared after surgery in all cases. The median value of prognostic nutritional factor was significantly increased postoperatively (36.0 [preoperatively] vs. 47.5, &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.0001). The median (interquartile range) values for lymphocyte-C-reactive protein ratio were 715.2 (110\u20132,607) preoperatively and 6,095.2 (1,612.3\u201314,431.8) postoperatively (&lt;i&gt;p&lt;\/i&gt; = 0.0214). The median survival of the entire cohort was 60.4 months. The 3-year survival rates for R0 + R1 and R2 cases were 83% and 24% (&lt;i&gt;p&lt;\/i&gt; = 0.018), respectively. Univariate analysis showed that R2 resection and low postoperative lymphocyte-C-reactive protein ratio were associated with poor prognosis. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Oophorectomy for ovarian metastasis from colorectal cancers was safely performed. It improved the patients\u2019 symptoms and nutritional status and may result in improved prognosis. <\/jats:p>","DOI":"10.1159\/000533599","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"114-121","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Oophorectomy on Survival and Improving Nutritional Status in Ovarian Metastasis from Colorectal Adenocarcinoma"],"prefix":"10.1159","volume":"102","author":[{"given":"Yusuke","family":"Miyagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Tokumaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Hondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7196"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02555331"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20803"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181b33cce"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-2029-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21382"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2011.12.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003239"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001122"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4236\/arsci.2016.42005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.12.039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90380-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6109(16)45934-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2015.02.009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1309\/G56H-97A2-JFMT-CD5N"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0796-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01543.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.02.025"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.12.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.05.006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S254876"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30424"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3862\/jcoloproctology.66.1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2007.11.012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1937.02780470006003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.09.007"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5235368"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1102-5"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2017-016"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.08.059"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.18"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.03.010"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1150-2"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/102\/2\/114\/4163726\/000533599.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/102\/2\/114\/4163726\/000533599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:01Z","timestamp":1745422681000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000533599","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","v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