{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:52Z","timestamp":1791499552723,"version":"4.3.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> DEL is known to be one of the weakest D variants, which can be detected by the adsorption-elution technique or by molecular study. Currently, in Thailand, we do not routinely test for DEL variants serologically or genetically among serologic RhD-negative blood donors. <b><i>Case Presentation:<\/i><\/b> We reported 2 cases of alloimmunization after transfused with Rh DEL, <i>RHD*DEL1<\/i> allele, in the Thai population. The first case was a 73-year-old male with anemia who presented with post-cardiac arrest and septic shock. The patient was group B, RhD-negative, and was transfused with RhD-negative red blood cells (RBCs). Antibody screening and identification found that the patient developed anti-D and anti-Mi<sup>a<\/sup> during the admission course. The second case was a 38-year-old woman with pseudomyxoma peritonei who developed anti-D after receiving four units of RhD-negative RBCs during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Both patients did not receive anti-D immunoglobulin and had no previous history of anti-D detection. We retrospectively investigated and found two units of <i>RHD*DEL1<\/i> among the RBCs transfused to these patients. <b><i>Discussion:<\/i><\/b> Previous reports of several cases of anti-D alloimmunization in RhD-negative recipients transfused by <i>RHD*DEL1<\/i>, an Asian-type DEL, are limited only to East Asia. We first identified 2 patients with anti-D alloimmunization after receiving the <i>RHD*DEL1<\/i> RBCs in the Thai population. This raises concern about Rh DEL screening among D-negative Thai blood donors and whether to remove DEL units from the D-negative inventory to improve patient safety. <\/jats:p>","DOI":"10.1159\/000533625","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"121-124","source":"Crossref","is-referenced-by-count":6,"title":["Two Cases of Anti-D Alloimmunization in D-Negative Thai Patients as a Result of the Asian-Type DEL on Transfused Red Cells"],"prefix":"10.1159","volume":"51","author":[{"given":"Kanyapon","family":"Suksard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komon","family":"Luangtrakool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thongbai","family":"Rungroung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutthisak","family":"Chamsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradermchai","family":"Saetam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulvara","family":"Kittisares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichart","family":"Permpikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janejira","family":"Kittivorapart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24685066827.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000499087"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v95.1.12"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/358316"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2450\/2013.0091-13"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03116-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00579.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2009.29.4.361"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100348"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2015.35.5.554"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103458"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018152"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3482124"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2450\/2022.0160-22"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17122"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12211"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/tmh\/article-pdf\/51\/2\/121\/4188221\/000533625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/tmh\/article-pdf\/51\/2\/121\/4188221\/000533625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:09Z","timestamp":1745422689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,2]]},"published-print":{"date-parts":[[2024,4,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000533625","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24083808","asserted-by":"subject"}]},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}