{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:30:33Z","timestamp":1759332633316,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Syndromol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Objective:<\/i><\/b> The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (<i>DRD2<\/i>) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels. <b><i>Methods:<\/i><\/b> One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of <i>DRD2<\/i> polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing. <b><i>Results:<\/i><\/b> In <i>DRD2<\/i> gene C957T (rs6277), three genotypes of CC, CT, and TT were detected with the frequencies of 92.67%, 6.67%, 0.67% in dyslipidemia cases, and 83.33%, 14.67%, 2.00% in the controls, respectively. The CT genotype and T allele frequencies were significantly low in the case group relative to the control group. After adjusting to other clinical indicators, the CT genotype of C957T polymorphism (hazard ratio = 0.401, 95% confidence interval = 0.181\u20130.890, <i>p<\/i> &lt; 0.05) was still related to a significantly reduced risk of dyslipidemia. The C957T CT genotype carriers had the lowest values of serum TC, TG, LDL, and the highest values of serum HDL-C. <b><i>Conclusion:<\/i><\/b> <i>DRD2<\/i> gene C957T polymorphism was an independent influencing factor associated with the susceptibility to dyslipidemia, and the CT genotype was associated with decreased odds of susceptibility to dyslipidemia. <\/jats:p>","DOI":"10.1159\/000533637","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"37-42","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population"],"prefix":"10.1159","volume":"15","author":[{"given":"Haibo","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maohua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jide","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08727-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12470"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2008.0082"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06970-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-122"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01256"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0632-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7709926"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.21.07347-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0924-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62362-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00053.2017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85503-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_658_21"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03644-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081217"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22254"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.07.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00184"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2020.0082"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109216"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.10.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091824"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.01.015"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1800155"}],"container-title":["Molecular Syndromology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/msy\/article-pdf\/15\/1\/37\/4167633\/000533637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/msy\/article-pdf\/15\/1\/37\/4167633\/000533637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:21Z","timestamp":1745422701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000533637","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24083460","asserted-by":"subject"}]},"ISSN":["1661-8769","1661-8777"],"issn-type":[{"type":"print","value":"1661-8769"},{"type":"electronic","value":"1661-8777"}],"subject":[],"published":{"date-parts":[[2023,9,13]]}}}