{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:50:34Z","timestamp":1769280634397,"version":"3.49.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Although ischemic stroke incidence has decreased in Sweden over the past decade, trends in spontaneous intracerebral hemorrhage (ICH) incidence are less well delineated. In this time period, there has been a dramatic increase in use of oral anticoagulants (OAC). The aim of our study was to investigate incidence trends in spontaneous first-ever ICH in Sweden between 2010 and 2019, with a focus on non-OAC-associated and OAC-associated ICH. Methods: We included patients (\u226518 years) with first-ever ICH registered in the hospital-based Swedish Stroke Register (Riksstroke) 2010\u20132019. Data were stratified by non-OAC and OAC ICH and analyzed for 2010\u20132012, 2013\u20132016, and 2017\u20132019. Incidence rates are shown as crude and age-specific per 100,000 person-years. Results: Between 2010 and 2019, 22,289 patients with first-ever ICH were registered; 18,325 (82.2%) patients with non-OAC ICH and 3,964 (17.8%) patients with OAC ICH. Annual crude incidence (per 100,000) of all first-ever ICH decreased by 10% from 29.5 (95% CI 28.8\u201330.3) to 26.7 (95% CI 26.0\u201327.3) between 2010\u20132012 and 2017\u20132019. The crude incidence rate of non-OAC ICH decreased by 20% from 25.7 (95% CI 25.0\u201326.3) to 20.7 (95% CI 20.1\u201321.2), whereas OAC ICH increased by 56% from 3.86 (95% CI 3.61\u20134.12) to 6.01 (95% CI 5.70\u20136.32). The proportion of OAC ICH of all first-ever ICH increased between 2010\u20132012 and 2017\u20132019 from 13.1% to 22.5% (p &amp;lt; 0.001). Proportional changes were largest in the age group \u226585 years with a decrease in non-OAC ICH by 32% from 155 (95% CI 146\u2013164) to 106 (95% CI 98.6\u2013113) and an increase in OAC ICH by 155% from 25.7 (95% CI 22.1\u201329.4) to 65.5 (95% CI 59.9\u201371.2). Conclusion: Incidence of first-ever ICH in Sweden decreased by 10% between 2010 and 2019. We found diverging trends with a 20% decrease in non-OAC-associated ICH and a 56% increase in OAC-associated ICH. Further research on ICH epidemiology, analyzing non-OAC and OAC-associated ICH separately, is needed to follow up these diverging trends including underlying risk factors. <\/jats:p>","DOI":"10.1159\/000533751","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"367-376","source":"Crossref","is-referenced-by-count":5,"title":["Diverging Trends in the Incidence of Spontaneous Intracerebral Hemorrhage in Sweden 2010\u20132019: An Observational Study from the Swedish Stroke Register (Riksstroke)"],"prefix":"10.1159","volume":"57","author":[{"given":"Conrad","family":"Drescher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Ullberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Pihlsg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Norrving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Petersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70025-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60371-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028484"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000527373"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000447719"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1512"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.819737"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30506-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.915813"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829e6ffa"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.42964"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15110"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211062011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000444679"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.69.5.0699"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211008770"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-022-01671-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019895662"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319849763"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00760"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000407"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.832903"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00003"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.031658"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318753"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100596"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013988"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62036-3"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2280-6"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001429"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016676285"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ned\/article-pdf\/57\/6\/367\/4062789\/000533751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ned\/article-pdf\/57\/6\/367\/4062789\/000533751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:51Z","timestamp":1745422791000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,18]]},"published-print":{"date-parts":[[2023,12,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000533751","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24024444","asserted-by":"subject"}]},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-p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