{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:54:47Z","timestamp":1761710087409,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel and is not readily available. Urinary biomarkers can be used as an adjunct. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to systematically review the diagnostic accuracy of urinary N terminal pro-B type natriuretic peptides (NT-proBNP) for hs-PDA in preterm neonates. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We included studies that evaluated urinary NT-proBNP and urinary NT-proBNP\/creatinine ratio (index tests) in preterm neonates with hs-PDA (participants) in comparison with echocardiogram (reference standard). Methodological quality and certainty of evidence were assessed using Quality Assessment of Diagnostic-Accuracy Studies (QUADAS-2) and Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Low quality of evidence suggests that urinary NT-proBNP has modest sensitivity and specificity for the diagnosis of a hs-PDA, with variation in accuracy based on assay and patient characteristics. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Urinary NT-proBNP assays must be locally validated for specific patient populations and further studies to support its use must be performed. <\/jats:p>","DOI":"10.1159\/000533824","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T21:02:04Z","timestamp":1698440524000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Accuracy of Urinary N Terminal pro-B Type Natriuretic Peptides for Hemodynamically Significant-Patent Ductus Arteriosus in Preterm Infants"],"prefix":"10.1159","volume":"121","author":[{"given":"Srirupa","family":"Hari Gopal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganga","family":"Gokulakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhulika","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caraciolo J.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Pammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000506988"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd013129.pub2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3506"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.21"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1995"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.588738"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.09.020"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.86"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.139"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000334826"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.179"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0603"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0581-9"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/1\/1\/4163752\/000533824.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/1\/1\/4163752\/000533824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:27Z","timestamp":1745422827000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000533824","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24375790","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2023,10,27]]}}}