{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:59:23Z","timestamp":1787605163259,"version":"build-2736575974"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Background:<\/i><\/b> Acitretin, a synthetic vitamin A derivative, is the most studied and widely used oral retinoid for ichthyoses. Its major disadvantage is the need for contraceptive measures during 3 years after discontinuation. An alternative is needed for women of childbearing age. With alitretinoin, another retinoid, pregnancy is considered safe 1 month after discontinuation. <b><i>Objectives:<\/i><\/b> The aim of this study was to provide evidence for alitretinoin as an alternative for acitretin for ichthyosis in women of childbearing age. Our experience is shared in a case series combined with an overview of the current literature. <b><i>Methods:<\/i><\/b> Nine women of childbearing age (19\u201331 years, median 21) with different subtypes of ichthyosis (autosomal recessive congenital ichthyosis, (superficial) epidermolytic ichthyosis, erythrokeratoderma variabilis, and epidermolytic epidermal nevi, a mosaic form of epidermolytic ichthyosis) were included and treated with 30 mg alitretinoin during 2\u201328 months. Severity was measured by Ichthyosis Area Severity Index (IASI) and Investigator Global Assessment (IGA). A literature search in Pubmed using the Mesh terms \u201calitretinoin,\u201d \u201cskin diseases, genetic\u201d and \u201cichthyosis\u201d was performed. <b><i>Results:<\/i><\/b> Significant reduction in the mean scores of IGA, IASI-erythema, IASI-scaling, and IASI-total was seen. Seven patients are still being treated, 1 patient stopped to become pregnant, 1 patient discontinued due to financial reasons. Observed side effects were reversible headache (<i>n<\/i> = 6), asteatotic eczema (<i>n<\/i> = 1), \u201cnot feeling well\u201d temporarily (<i>n<\/i> = 1), and easier blistering of the feet (<i>n<\/i> = 1). The literature search resulted in six case reports and case series about alitretinoin in ichthyosis and ichthyosis syndromes with in total 29 patients. The vast majority of articles (21\/29) reported significant improvement or even complete remission of skin symptoms. However, validated outcome measures to support these results were lacking. Side effects (<i>n<\/i> = 16) were relatively mild, except for benign intracranial hypertension (<i>n<\/i> = 1) and autoimmune hypothyroidism (<i>n<\/i> = 1). <b><i>Conclusion:<\/i><\/b> Our study shows, with validated outcome measures, that alitretinoin is effective to mitigate the symptoms of ichthyosis in women of childbearing age and a suitable alternative to acitretin. <\/jats:p>","DOI":"10.1159\/000533934","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:55:40Z","timestamp":1695711340000},"page":"170-177","source":"Crossref","is-referenced-by-count":4,"title":["Alitretinoin as a Treatment Modality for Ichthyosis in Women of Childbearing Age: A Case Series and Review of the Literature"],"prefix":"10.1159","volume":"240","author":[{"given":"Julia","family":"Clabbers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor van","family":"van Oosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Bolling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"Vreeburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"van Geel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Steijlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Gostynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17203"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14408"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01527.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.12.26"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.3.9364"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08487.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.216"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1302"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1499"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1447"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16318"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0783-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.09.054"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12366"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12348"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14327"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.909"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.1998457"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15382"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/1\/170\/4167646\/000533934.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/1\/170\/4167646\/000533934.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:41:31Z","timestamp":1745422891000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000533934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000533934","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]}}}