{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:28:44Z","timestamp":1776954524432,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Glucocorticoid (GC) treatment suppresses the hypothalamic-pituitary-adrenal axis and can cause GC-induced adrenal insufficiency. In this study, we investigated the incidence of GC-induced adrenal insufficiency in patients receiving intermittent short-term high-dose oral GC treatment for newly diagnosed diffuse large B-cell lymphoma. Cosyntropin stimulation test was used to assess adrenal function at study entry (baseline), at 2 months (before the 5th cycle), and 6 months from baseline (3 months after the last cycle). Ten patients were included (40% women). Mean age was 61 years. The mean (range) plasma morning cortisol was 407 (320\u2013530) nmol\/L at baseline, 373 (260\u2013610) nmol\/L at 2 months, and 372 (230\u2013520) nmol\/L at 6 months from baseline. All patients had normal response to cosyntropin stimulation at baseline as well as 2 and 6 months from baseline. Thus, none of the patients developed biochemically verified adrenal insufficiency. Therefore, short-term high-dose GC therapy, a commonly used adjuvant treatment in patients with malignant hematological diseases, does not seem to down-regulate the hypothalamic-pituitary-adrenal axis. <\/jats:p>","DOI":"10.1159\/000534317","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"360-365","source":"Crossref","is-referenced-by-count":2,"title":["Intermittent High-Dose Glucocorticoid Treatment Does Not Cause Adrenal Insufficiency in Patients with Diffuse Large B-Cell Lymphoma: A Prospective Study"],"prefix":"10.1159","volume":"147","author":[{"given":"Margret Jona","family":"Einarsdottir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hallgerdur L.","family":"Kristjansdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnhildur","family":"Bergthorsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope","family":"Trimpou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Lewerin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Ragnarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199201233260403"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1218"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-3-200308050-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(79)91077-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182260cbe"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3470-y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060710"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12162"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1710"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.3.5535"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0710"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1700"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0746"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060806"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000440834"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/147\/3\/360\/4232381\/000534317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/147\/3\/360\/4232381\/000534317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:29Z","timestamp":1745423129000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000534317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,5,28]]},"published-print":{"date-parts":[[2024,5,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000534317","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]}}}