{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:44:21Z","timestamp":1783943061790,"version":"3.55.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> There is a great clinical need for novel markers to predict kidney function decline in patients with type 2 diabetes. We explored the potential of posttranslationally modified fetuin-A fragments in urine (uPTM-FetA) as such a marker. <b><i>Methods:<\/i><\/b> We included patients with type 2 diabetes from two independent, nonoverlapping prospective cohort studies. A cut-off for uPTM-FetA, measured via ELISA method, was determined using the Youden index in the primary cohort of patients with type 2 diabetes from Taiwan. Kidney endpoint was defined as an estimated glomerular filtration rate (eGFR) decline \u226530% from baseline, reaching of an eGFR &lt;15 mL\/min\/1.73 m<sup>2<\/sup>, or a need of renal replacement therapy. Prospective associations were assessed in Cox regression models. All analyses were replicated in a cohort of patients with type 2 diabetes from the Netherlands. <b><i>Results:<\/i><\/b> In total, 294 patients with type 2 diabetes (age 61 \u00b1 10 years, 55% male, eGFR 88 \u00b1 16 mL\/min\/1.73 m<sup>2<\/sup>) were included in the primary cohort. During a follow-up of median 4.6 years, 42 participants (14%) experienced the kidney endpoint. Using the defined cut-off, a high uPTM-FetA was associated with a higher risk of renal function decline (<i>P<\/i><sub>log-rank<\/sub> &lt; 0.0001). This association was similar in subgroups depending on albuminuria. This association remained, independent of age, sex, baseline eGFR, albuminuria, HbA1c, and other potential confounders (HR: 9.94; 95% CI: 2.96\u201333.40; <i>p<\/i> &lt; 0.001 in the final model). Analyses in the validation cohort (376 patients with type 2 diabetes, age 64 \u00b1 11 years, 66% male, eGFR 76 \u00b1 24 mL\/min\/1.73 m<sup>2<\/sup>) using the same cut-off yielded similar results. <b><i>Conclusion:<\/i><\/b> uPTM-FetA was independently associated with kidney function decline in patients with type 2 diabetes validated in a 2-cohort study. The significant additive predictive power of this biomarker from conventional risk factors suggests its clinical use for renal function progression in patients with type 2 diabetes. <\/jats:p>","DOI":"10.1159\/000534514","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"106-114","source":"Crossref","is-referenced-by-count":10,"title":["Urinary Fetuin-A Fragments Predict Progressive Estimated Glomerular Filtration Rate Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities"],"prefix":"10.1159","volume":"55","author":[{"given":"Gwo-Tsann","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas F.","family":"Alkaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Ling","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozewijn D.","family":"Laverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Ming","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1296"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11491116"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.08.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76773-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283456546"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00462-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4567-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.04.06.dc05-1938"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0538"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.06.0011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3177-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.145"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.02.685"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070709"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.07.030"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.06.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj063"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.13.4403"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077118"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa176"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.59.691.304"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030676"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00329.2012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001874"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20832-7"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ajn\/article-pdf\/55\/1\/106\/4163526\/000534514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ajn\/article-pdf\/55\/1\/106\/4163526\/000534514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:47:46Z","timestamp":1745423266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000534514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000534514","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24427183","asserted-by":"subject"}]},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]}}}