{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:05:40Z","timestamp":1776891940965,"version":"3.51.2"},"reference-count":34,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The primary aim was to analyze any coupling of heart rate (HR)\/arterial oxygen saturation (SpO<sub>2<\/sub>) and regional cerebral oxygen saturation (rScO<sub>2<\/sub>) and regional cerebral fractional tissue oxygen extraction (cFTOE) during immediate transition after birth in term and preterm neonates to gain more insight into interactions. <b><i>Methods:<\/i><\/b> The present study is a post hoc analysis of data from 106 neonates, obtained from a prospective, observational study. Measurements of HR, SpO<sub>2<\/sub>, rScO<sub>2<\/sub>, and cFTOE were performed during the first 15 min after birth. The linear and nonlinear correlation were computed between these parameters in a sliding window. The resulting coupling curves were clustered. After clustering, demographic data of the clusters were de-blinded and compared. <b><i>Results:<\/i><\/b> Due to missing data, 58 out of 106 eligible patients were excluded. Two clusters were obtained: cluster 1 (<i>N =<\/i> 39) and cluster 2 (<i>N =<\/i> 9). SpO<sub>2<\/sub> had linear and nonlinear correlations with rScO<sub>2<\/sub> and cFTOE, whereby the correlations with rScO<sub>2<\/sub> were more pronounced in cluster 2. HR-rScO<sub>2<\/sub> and HR-cFTOE demonstrated a nonlinear correlation in both clusters, again being more pronounced in cluster 2, whereby linear correlations were mainly absent. After de-blinding, the demographic data revealed that the neonates in cluster 2 had significantly lower gestational age (mainly preterm) compared to cluster 1 (mainly term). <b><i>Discussion:<\/i><\/b> Besides SpO<sub>2<\/sub>, also HR demonstrated a nonlinear correlation with rScO<sub>2<\/sub> and cFTOE in term and preterm neonates during immediate transition after birth. In addition, the coupling of SpO<sub>2<\/sub> and HR with cerebral oxygenation was more pronounced in neonates with a lower gestational age. <\/jats:p>","DOI":"10.1159\/000534524","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T21:00:31Z","timestamp":1712610031000},"page":"421-430","source":"Crossref","is-referenced-by-count":1,"title":["Coupling between Regional Oxygen Saturation of the Brain and Vital Signs during Immediate Transition after Birth"],"prefix":"10.1159","volume":"121","author":[{"given":"Dries","family":"Hendrikx","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Caicedo Dorado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Van 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