{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:02:57Z","timestamp":1782172977381,"version":"3.54.5"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Chronic prurigo (CPG) is an inflammatory skin disease. Comorbidities including dermatological, cardiovascular, and psychiatric diseases have been reported in patients with CPG; however, the evidence has not been systematically evaluated. We aim to summarize the comorbidities, discuss underlying pathogenesis, and highlight the evaluation of CPG patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We performed a systematic search using PubMed, Embase, and Web of Science databases for all articles reporting possible associated diseases with CPG. Pooled random-effects odds ratios (ORs) with 95% CI were calculated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 17 studies were included in this systematic review. Statistically significant association (&lt;i&gt;p&lt;\/i&gt; &amp;lt;0.05) with CPG has been demonstrated with atopic diseases: atopic dermatitis (pooled OR, 10.91; 95% CI, 3.65\u201332.67), allergic rhinitis (2.66; 1.12\u20136.27), asthma (3.23; 1.55\u20136.74); infectious diseases: hepatitis B (pooled OR, 2.15; 95% CI, 1.11\u20134.14); endocrine diseases: diabetes (pooled OR, 4.93; 95% CI, 1.13\u201321.56), type 1 diabetes (2.46; 2.16\u20132.81), type 2 diabetes (1.89; 1.34\u20132.68), hyperlipoproteinemia (2.90; 1.61\u20135.22); cardiovascular diseases: heart failure (pooled OR, 4.13; 95% CI, 1.15\u201314.91), hypertension (3.17; 1.56\u20136.45); respiratory system diseases: chronic obstructive pulmonary disease (pooled OR, 3.19; 95% CI, 1.42\u20137.16); urinary system diseases: chronic kidney disease (pooled OR, 4.16; 95% CI, 1.79\u20139.66); digestive system disease: inflammatory bowel disease (pooled OR, 2.06; 95% CI, 1.26\u20133.36); and others: osteoporosis (pooled OR, 3.08; 95% CI, 1.70\u20135.59), thyroid disease (1.70; 1.17\u20132.47). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; CPG is associated with various systemic disorders. Recognition of comorbidities is critical to the appropriate management of affected patients. <\/jats:p>","DOI":"10.1159\/000534660","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T21:00:45Z","timestamp":1698354045000},"page":"32-41","source":"Crossref","is-referenced-by-count":9,"title":["Comorbidities of Chronic Prurigo: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"240","author":[{"given":"Mengting","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chener","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,10,26]]},"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/1\/32\/4167702\/000534660.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/1\/32\/4167702\/000534660.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:17Z","timestamp":1745423357000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000534660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000534660","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24565090","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]}}}