{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:35:30Z","timestamp":1772721330645,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Published data on the association between the &lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 polymorphism and gestational diabetes mellitus (GDM) risk are controversial. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; A meta-analysis was performed to assess whether the polymorphism of &lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 is associated with GDM risk. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for &lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 polymorphism and GDM were appropriately derived from fixed-effects or random effects models. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 8 studies were enrolled in this meta-analysis. The pooled analyses revealed that &lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 polymorphism significantly increased the risk of GDM in all models (allele contrast (C vs. T): OR, 0.78; 95% CI, 0.73\u20130.83; homozygote (CC vs. TT): OR, 0.61; 95% CI, 0.53\u20130.69; heterozygote (CT vs. TT): OR, 0.78; 95% CI, 0.69\u20130.89; dominant model (CC + CT vs. TT): OR, 0.71; 95% CI, 0.63\u20130.80; recessive model (CC vs. CT + TT): OR, 0.73; 95% CI, 0.67\u20130.81). Further subgroup analyses by ethnicity of participants yielded similar positive results. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Present meta-analysis reveals that &lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 variant may serve as genetic biomarkers of GDM. <\/jats:p>","DOI":"10.1159\/000535148","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:00:31Z","timestamp":1700258431000},"page":"201-211","source":"Crossref","is-referenced-by-count":5,"title":["&lt;i&gt;MTNR1B&lt;\/i&gt; rs1387153 Polymorphism and Risk of Gestational Diabetes Mellitus: Meta-Analysis and Trial Sequential Analysis"],"prefix":"10.1159","volume":"26","author":[{"given":"Dan","family":"Shan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,11,17]]},"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/phg\/article-pdf\/26\/1\/201\/4060909\/000535148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/phg\/article-pdf\/26\/1\/201\/4060909\/000535148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:29Z","timestamp":1745423669000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000535148","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"value":"1662-4246","type":"print"},{"value":"1662-8063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}