{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:51Z","timestamp":1745468751234,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Hyaluronan (HA) is a major component of the extracellular matrix. Increased pulmonary HA concentrations are associated with several respiratory disorders and is a pathophysiological feature of lung disease. We investigated whether elevated urine HA is a biomarker of an unfavorable 40-week respiratory outcome in preterm infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Infants comprised a cohort of preterm neonates &amp;lt;31 weeks gestational age (GA) from the Prematurity-Related Ventilatory Control (Pre-Vent) multicenter study. HA was quantified in urine obtained at 1 week and 1 month of age. Respiratory status at 40 weeks post-menstrual age (PMA) was classified as unfavorable [either (1) deceased at or before 40 weeks PMA, (2) an inpatient on respiratory medication, O&lt;sub&gt;2&lt;\/sub&gt; or other respiratory support at 40 weeks, or (3) discharged prior to 40 weeks on medications\/O&lt;sub&gt;2&lt;\/sub&gt;\/other respiratory support], or favorable (alive and previously discharged, or inpatient and off respiratory medications, off O&lt;sub&gt;2&lt;\/sub&gt;, and off other respiratory support at 40 weeks PMA). The association between urine HA and the unfavorable 40 week PMA outcome was examined using a multivariate logistic generalized estimation equation model. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Infants with higher HA at 1 week (but not 1 month) showed increased odds of unfavorable respiratory outcome at 40 weeks PMA (OR [95% CI] = 1.87 per 0.01 mg [1.27, 2.73]). &lt;b&gt;&lt;i&gt;Discussion and Conclusion:&lt;\/i&gt;&lt;\/b&gt; Neonatal urine screening for HA could identify infants at risk for death or need for respiratory support at term-corrected age (40 weeks PMA). The relationship between elevated HA at 1 week and an unfavorable 40 week outcome was stronger in infants with lower GA. <\/jats:p>","DOI":"10.1159\/000535185","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T22:00:26Z","timestamp":1710453626000},"page":"468-477","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Urine Hyaluronan Concentrations Are Associated with an Unfavorable Respiratory Outcome in Preterm Neonates at 40 Weeks Postmenstrual Age"],"prefix":"10.1159","volume":"121","author":[{"given":"Peter Mathew","family":"MacFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nori","family":"Minich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Ann","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard John","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliann Marie","family":"Di Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Michael","family":"Raffay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Hibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00168.2015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/712507"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.06.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000072302"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199402000-00024"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-652OC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.13.6.7576700"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199811000-00014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103465"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0317-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02620-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02646-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202210-1971OC"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000509038"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.020842"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.2.96-08040"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200803-386OC"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.682"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90306.2008"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01695-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101485"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040824"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/468\/4264179\/000535185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/468\/4264179\/000535185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:58Z","timestamp":1745423698000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000535185","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25162409","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2024]]}}}