{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:32:13Z","timestamp":1791919933795,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; (&lt;i&gt;S. aureus&lt;\/i&gt;) is a common cause of hospital- and community-acquired infections that can result in various clinical manifestations ranging from mild to severe disease. The bacterium utilizes different combinations of virulence factors and biofilm formation to establish a successful infection, and the emergence of methicillin- and vancomycin-resistant strains introduces additional challenges for infection management and treatment. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; Metabolic programming of immune cells regulates the balance of energy requirements for activation and dictates pro- versus anti-inflammatory function. Recent investigations into metabolic adaptations of leukocytes and &lt;i&gt;S. aureus&lt;\/i&gt; during infection indicate that metabolic crosstalk plays a crucial role in pathogenesis. Furthermore, &lt;i&gt;S. aureus&lt;\/i&gt; can modify its metabolic profile to fit an array of niches for commensal or invasive growth. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; Here we focus on the current understanding of immunometabolism during &lt;i&gt;S. aureus&lt;\/i&gt; infection and explore how metabolic crosstalk between the host and &lt;i&gt;S. aureus&lt;\/i&gt; influences disease outcome. We also discuss how key metabolic pathways influence leukocyte responses to other bacterial pathogens when information for &lt;i&gt;S. aureus&lt;\/i&gt; is not available. A better understanding of how &lt;i&gt;S. aureus&lt;\/i&gt; and leukocytes adapt their metabolic profiles in distinct tissue niches may reveal novel therapeutic targets to prevent or control invasive infections.<\/jats:p>","DOI":"10.1159\/000535482","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T17:00:27Z","timestamp":1701277227000},"page":"12-30","source":"Crossref","is-referenced-by-count":35,"title":["Metabolism Shapes Immune Responses to &lt;i&gt;Staphylococcus aureus&lt;\/i&gt;"],"prefix":"10.1159","volume":"16","author":[{"given":"Prabhakar","family":"Arumugam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Kielian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,11,28]]},"container-title":["Journal of Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/jin\/article-pdf\/16\/1\/12\/4165494\/000535482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/jin\/article-pdf\/16\/1\/12\/4165494\/000535482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:57:54Z","timestamp":1745409474000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000535482","archive":["Portico"],"relation":{},"ISSN":["1662-811X","1662-8128"],"issn-type":[{"value":"1662-811X","type":"print"},{"value":"1662-8128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]}}}