{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:13:49Z","timestamp":1786500829663,"version":"build-2736575974"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Head and neck photoimmunotherapy (HN-PIT) uses a combination of drugs and laser illumination to specifically destroy tumor cells. Lemierre\u2019s syndrome is an infectious disease with severe systemic symptoms caused by prior infection in the pharyngeal region, leading to thrombophlebitis. Here, we report a case of Lemierre\u2019s syndrome that developed after HN-PIT for recurrent nasopharyngeal carcinoma. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; A 68-year-old male with nasopharyngeal carcinoma (squamous cell carcinoma) underwent HN-PIT after local recurrence with chemoradiation therapy. Three months after HN-PIT, the patient developed fever and neck pain, which led to a diagnosis of Lemierre\u2019s syndrome. The patient was treated with antibiotics and anticoagulants for at least 1 month. The patient\u2019s general condition and inflammatory findings on blood sampling showed gradual improvement, and a follow-up cervicothoracic computed tomography imaging showed that the venous thrombus had been obscured and the patient was doing well. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; HN-PIT is a high-risk procedure for the development of Lemierre\u2019s syndrome due to irradiation-induced mucositis, and anticipating the development of Lemierre\u2019s syndrome during HN-PIT is important. <\/jats:p>","DOI":"10.1159\/000535597","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T22:01:59Z","timestamp":1706824919000},"page":"180-185","source":"Crossref","is-referenced-by-count":8,"title":["Lemierre\u2019s Syndrome after Head and Neck Photoimmunotherapy for Local Recurrence of Nasopharyngeal Carcinoma"],"prefix":"10.1159","volume":"17","author":[{"given":"Midori","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaku","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Tokashiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoaki","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2554"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-021-01960-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2022.06.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000202209.42491.38"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184413"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4236\/ijohns.2022.115027"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225662"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12799"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000521435"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S95050"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198903000-00002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.11.009"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/180\/4163555\/000535597.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/180\/4163555\/000535597.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:59:02Z","timestamp":1745423942000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000535597","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25127000","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]}}}