{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:36:42Z","timestamp":1790757402819,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Evidence on the cost-effectiveness of comprehensive post-stroke programs is limited. We assessed the cost-effectiveness of an individualised management program (IMP) for stroke or transient ischaemic attack (TIA). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A cost-utility analysis alongside a randomised controlled trial with a 24-month follow-up, from both societal and health system perspectives, was conducted. Adults with stroke\/TIA discharged from hospitals were randomised by primary care practice to receive either usual care (UC) or an IMP in addition to UC (intervention). An IMP included stroke-specific nurse-led education and a specialist review of care plans at baseline, 3 months, and 12 months, and telephone reviews by nurses at 6 months and 18 months. Costs were expressed in 2021 Australian dollars (AUD). Costs and quality-adjusted life years (QALYs) beyond 12 months were discounted by 5%. The probability of cost-effectiveness of the intervention was determined by quantifying 10,000 bootstrapped iterations of incremental costs and QALYs below the threshold of AUD 50,000\/QALY. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among the 502 participants (65% male, median age 69 years), 251 (50%) were in the intervention group. From a health system perspective, the incremental cost per QALY gained was AUD 53,175 in the intervention compared to the UC group, and the intervention was cost-effective in 46.7% of iterations. From a societal perspective, the intervention was dominant in 52.7% of iterations, with mean per-person costs of AUD 49,045 and 1.352 QALYs compared to mean per-person costs of AUD 51,394 and 1.324 QALYs in the UC group. The probability of the cost-effectiveness of the intervention, from a societal perspective, was 60.5%. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Care for people with stroke\/TIA using an IMP was cost-effective from a societal perspective over 24 months. Economic evaluations of prevention programs need sufficient time horizons and consideration of costs beyond direct healthcare utilisation to demonstrate their value to society.<\/jats:p>","DOI":"10.1159\/000535638","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T17:04:37Z","timestamp":1708016677000},"page":"156-165","source":"Crossref","is-referenced-by-count":10,"title":["Cost-Effectiveness of an Individualised Management Program after Stroke: A Trial-Based Economic Evaluation"],"prefix":"10.1159","volume":"58","author":[{"given":"Zhomart","family":"Orman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muideen T.","family":"Olaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Thrift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique A.","family":"Cadilhac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velandai K.","family":"Srikanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Bladin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Gerraty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Phillipos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joosup","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009103.pub3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/1474515118779732"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211016963"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac245"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100723"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.634949"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12482"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00933.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13306"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-03066-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017499"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016229"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00205"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12195"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008815005736"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2018.06.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3402\/jmahp.v1i0.21240"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1481"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(98)00151-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008585"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05103-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1071\/AH09742"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.125708"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13281"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462316000027"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.02.005"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ned\/article-pdf\/58\/3\/156\/4237233\/000535638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ned\/article-pdf\/58\/3\/156\/4237233\/000535638.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:59:43Z","timestamp":1745409583000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,4]]},"published-print":{"date-parts":[[2024,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000535638","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25225103","asserted-by":"subject"}]},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}