{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:10:44Z","timestamp":1791688244220,"version":"4.3.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Functional dyspepsia (FD) is a chronic relapsing gastroduodenal disorder with limited treatment options. Herbal products, like the six-herb combination STW 5-II, can target multiple FD gastrointestinal symptoms. In this meta-analysis, we evaluated the efficacy and safety of STW 5-II for overall FD, and key symptoms, based on Rome IV criteria. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We systematically screened the literature for randomized controlled clinical studies testing STW 5-II in FD. Meta-analysis was performed using data from individual patients with at least one key FD symptom (fullness, early satiety, or epigastric pain) of at least moderate severity at baseline. ANCOVA-based meta-analyses were performed on improvements in the total symptom sum score, and single symptoms, after 4 and 8 weeks. Safety data were analyzed by calculating odds ratios for all adverse events. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four randomized controlled trials, including 613 patients, were identified, and two were eligible for efficacy analysis. STW 5-II significantly improved the FD symptom sum score (mean difference of 1.74 after 4 weeks and 2.07 after 8 weeks) and key FD symptoms of fullness (0.28 and 0.29), early satiety (0.25 and 0.26), and epigastric\/upper abdominal pain (0.26 and 0.3). Treatment-related or severe adverse events did not differ between STW 5-II and placebo. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The results support that STW 5-II significantly improves FD symptoms after 4 and 8 weeks of treatment with no difference in relation to safety signals compared to placebo. Thus, STW 5-II can be considered an effective and safe treatment option for FD. <\/jats:p>","DOI":"10.1159\/000535672","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T22:00:32Z","timestamp":1709157632000},"page":"166-174","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis"],"prefix":"10.1159","volume":"105","author":[{"given":"Viola","family":"Andresen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Careen","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Rabini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wargenau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2661"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30003-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.81"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.05.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12355"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32130"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000076546"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13984"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01232.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1351837"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00393"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153589"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ph15091121"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1690"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-020-01107-x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd013323.pub2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14527"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00102-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000504570"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/105\/3\/166\/4235329\/000535672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/105\/3\/166\/4235329\/000535672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:00:14Z","timestamp":1745424014000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,3]]},"published-print":{"date-parts":[[2024,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000535672","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}