{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:12:50Z","timestamp":1790107970770,"version":"4.0.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The role of catechol-O-methyltransferase (COMT) in catecholamine neurotransmitter metabolism has led to the investigation of variants of the corresponding gene in the etiology of different psychiatric disorders, but the results are inconclusive. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We have examined the relationship between &lt;i&gt;COMT&lt;\/i&gt; Val158Met single nucleotide polymorphism (rs4680) and the occurrence of psychiatric disorders in a highly representative birth cohort sample of young adults in the Estonian Children Personality Behaviour and Health Study (original &lt;i&gt;n&lt;\/i&gt; = 1,238). The lifetime occurrence of psychiatric disorders at the age of 25 years was assessed with the Mini-International Neuropsychiatric Interview. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both Val- and Met-alleles of the &lt;i&gt;COMT&lt;\/i&gt; Val158Met were associated with specific psychiatric disorders. Met-allele carriers had a significantly higher occurrence of agoraphobia (3.2% vs. 0.5%; \u03c7&lt;sup&gt;2&lt;\/sup&gt; = 4.10; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.05) compared to Val\/Val homozygotes. Also, the occurrence of panic disorder was significantly higher in female Met-allele carriers than in Val\/Val homozygote females (10.2% vs. 3.6%; \u03c7&lt;sup&gt;2&lt;\/sup&gt; = 4.62 &lt;i&gt;p&lt;\/i&gt; = 0.03). In contrast, the occurrence of generalized anxiety disorder was higher in Val\/Val females when compared to Met-allele carriers (12.7% vs. 6.8%; \u03c7&lt;sup&gt;2&lt;\/sup&gt; = 4.16; &lt;i&gt;p&lt;\/i&gt; = 0.04). Also, female Val\/Val homozygotes (15.5%) had a higher occurrence of eating disorders than Met-allele carriers (6.1%) of the &lt;i&gt;COMT&lt;\/i&gt; Val158Met polymorphism (\u03c7&lt;sup&gt;2&lt;\/sup&gt; = 10.39; &lt;i&gt;p&lt;\/i&gt; = 0.002). In the whole sample, Met-allele homozygotes had a higher occurrence of alcohol use and substance use disorders than Val-allele carriers (\u03c7&lt;sup&gt;2&lt;\/sup&gt; = 3.62 and 3.68, respectively; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In a regional highly birth cohort representative sample, either &lt;i&gt;COMT&lt;\/i&gt; rs4680 variant was observed in association with specific psychiatric disorders. <\/jats:p>","DOI":"10.1159\/000535912","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T22:00:36Z","timestamp":1705442436000},"page":"41-48","source":"Crossref","is-referenced-by-count":5,"title":["&lt;i&gt;To Each His Own Fear&lt;\/i&gt;: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either &lt;i&gt;COMT&lt;\/i&gt; Val158Met allele"],"prefix":"10.1159","volume":"83","author":[{"given":"Evelyn","family":"Kiive","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triin","family":"Kurrikoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toomas","family":"Veidebaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaanus","family":"Harro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,1,16]]},"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nps\/article-pdf\/83\/1\/41\/4169441\/000535912.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nps\/article-pdf\/83\/1\/41\/4169441\/000535912.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:02:32Z","timestamp":1745424152000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000535912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,15]]},"published-print":{"date-parts":[[2024,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000535912","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}