{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:28Z","timestamp":1787017948306,"version":"build-2736575974"},"reference-count":37,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate if a negative test result for &lt;i&gt;MYD88&lt;\/i&gt; L265P mutation, associated with vitreoretinal lymphoma (VRL) and primary CNS lymphoma, in liquid biopsies from intraocular fluids can be a useful adjuvant test to diagnose chronic lymphocytic leukemia in clinically challenging cases. &lt;b&gt;&lt;i&gt;Case Presentations:&lt;\/i&gt;&lt;\/b&gt; We selected patients with a past medical history or examinations findings suspicious for intraocular lymphoma. We evaluated both vitreous and aqueous humor-derived (AHD) &lt;i&gt;MYD88&lt;\/i&gt; L265P mutation from patients that had suspected intraocular lymphoma that warranted a liquid biopsy procedure. Gold-standard cytopathology, flow cytometry, and gene rearrangement studies were also performed. All 4 patients had negative AHD &lt;i&gt;MYD88&lt;\/i&gt; L265P mutation testing. Gold-standard testing (cytology) either showed paucicellular specimens (1\/4) or specimens with high background inflammation (3\/4). One case showed a rare B-cell clonal population (CD5&lt;sup&gt;+&lt;\/sup&gt;, Kappa-restricted by flow cytometry), but this was not sufficient to make any definitive diagnosis. All patients were subsequently initiated on systemic therapy and had improvement in their disease burden. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Negative AHD &lt;i&gt;MYD88&lt;\/i&gt; L265P mutation testing can serve as an adjuvant molecular test to diagnose difficult cases of intraocular CLL.<\/jats:p>","DOI":"10.1159\/000535951","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T18:01:01Z","timestamp":1711389661000},"page":"103-113","source":"Crossref","is-referenced-by-count":2,"title":["Posterior Uveitis in Ocular-Involving Chronic Lymphocytic Leukemia and the Utility of Negative MYD88 L265P Testing in the Diagnosis"],"prefix":"10.1159","volume":"10","author":[{"given":"Daniel A.","family":"Balikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor 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