{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:11:31Z","timestamp":1793743891733,"version":"4.6.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; This study aimed to investigate the associations of digital ulcers (DUs) in patients with systemic sclerosis (SSc). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This retrospective study investigated the demographic characteristics, specific autoantibodies, organ involvement, and laboratory tests in patients with SSc from our hospital. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This study enrolled 144 patients with SSc. The DU+ group consisted of 15 (10.4%) patients. Patients with SSc having DUs have longer disease duration, higher fibrinogen, higher fibrin degradation product, and lower cholesterol. None of the patients used cholesterol-lowering drugs before onset of DUs. The study also demonstrated a higher prevalence of anti-dsDNA and anti-histone antibodies in patients with SSc with DUs. Anti-dsDNA antibody is a specific antibody for SLE with a specificity of 96\u201399%. A total of 86.1% (124\/144) of patients suffered from diffuse cutaneous SSc, and 28.5% (41\/144) of patients suffered from overlap syndrome. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our study indicated that patients with SSc with fibrinogen of &amp;gt;2.895 g\/L (&lt;i&gt;p&lt;\/i&gt; = 0.043) and cholesterol of &amp;lt;3.340 mmol\/L (&lt;i&gt;p&lt;\/i&gt; = 0.036), which is equal to 129.258 mg\/dL, are at high risk of developing DUs. <\/jats:p>","DOI":"10.1159\/000536030","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T22:00:36Z","timestamp":1711058436000},"page":"387-396","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Digital Ulcers in Patients with Systemic Sclerosis: An 8-Year Retrospective Study"],"prefix":"10.1159","volume":"240","author":[{"given":"Miaomiao","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0551-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000551"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/ar4230"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.149"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep105"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/art.20676"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209481"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205897"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207271"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.04.007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20336"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200631"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.116779"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.72662"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.191"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8191-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00541"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.037"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.3.345"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg170"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1507638"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0290-8"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/3\/387\/4240459\/000536030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/3\/387\/4240459\/000536030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:03:53Z","timestamp":1745424233000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,11]]},"published-print":{"date-parts":[[2024,6,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000536030","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}