{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:26:54Z","timestamp":1783967214959,"version":"3.55.0"},"reference-count":84,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; &lt;sc&gt;d&lt;\/sc&gt;-Chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; This perspective seeks to explore the mechanisms and functions of &lt;sc&gt;d&lt;\/sc&gt;-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A narrative review of all the relevant papers known to the authors was conducted. &lt;b&gt;&lt;i&gt;Outcome:&lt;\/i&gt;&lt;\/b&gt; &lt;sc&gt;d&lt;\/sc&gt;-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue\/brown adipose tissue transdifferentiation. These different modes of action have potential applications in a variety of therapeutic fields, including PCOS, dysmetabolism, obesity, hypoestrogenic\/hyperandrogenic disorders, and bone health. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; &lt;sc&gt;d&lt;\/sc&gt;-Chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between &lt;sc&gt;d&lt;\/sc&gt;-chiro-inositol and its isomer myo-inositol. The insulin-sensitizing activities of &lt;sc&gt;d&lt;\/sc&gt;-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic\/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study. <\/jats:p>","DOI":"10.1159\/000536081","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T22:00:31Z","timestamp":1711663231000},"page":"284-294","source":"Crossref","is-referenced-by-count":9,"title":["&lt;sc&gt;d&lt;\/sc&gt;-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research 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