{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:04:39Z","timestamp":1774451079761,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Knowledge about uptake and workflow metrics of hyperacute treatments in patients with non-traumatic intracerebral haemorrhage (ICH) in the emergency department is scarce. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Single-centre retrospective study of consecutive patients with ICH between 01\/2018\u201308\/2020. We assessed uptake and workflow metrics of acute therapies overall and according to referral mode (stroke code, transfer from other hospital, or other). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We enrolled 332 patients (age 73 years, IQR: 63\u201381 and GCS 14 points, IQR: 11\u201315, onset-to-admission time 284 min, IQR: 111\u2013708 min), of whom 101 patients (35%) had lobar haematoma. Mode of referral was stroke code in 129 patients (38%), transfer from other hospital in 143 patients (43%), and arrival by other means in 60 patients (18%). Overall, 143 of 216 (66%) patients with systolic blood pressure &amp;gt;150 mm Hg received IV-antihypertensive treatment, and 67 of 76 (88%) on therapeutic oral anticoagulation received prothrombin complex concentrate treatment (PCC). Forty-six patients (14%) received any neurosurgical intervention within 3 h of admission. Median treatment times from admission to first IV-antihypertensive treatment were 38 min (IQR: 18\u201372 min) and 59 min (IQR: 37\u2013111 min) for PCC, with significant differences according to mode of referral (&lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) but not early arrival (\u22646 h of onset, &lt;i&gt;p&lt;\/i&gt; = 0.92). The median time in the emergency department was 139 min (IQR: 85\u2013220 min), and among patients with elevated blood pressure, only 44% achieved a successful control (&amp;lt;140 mm Hg) during ED stay. In multivariate analysis, code ICH concordant treatment was associated with significantly lower odds for in-hospital mortality (aOR 0.30, 95% CI: 0.12\u20130.73, &lt;i&gt;p&lt;\/i&gt; = 0.008) and non-significant trends towards better functional outcome measured using the modified Rankin scale score at 3 months (aOR for ordinal shift 0.54, 95% CI: 0.26\u20131.12, &lt;i&gt;p&lt;\/i&gt; = 0.097). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Uptake of hyperacute therapies for ICH treatment in the ED is heterogeneous. Treatment delays are short, but not all patients achieve treatment targets during ED stay. Code ICH-concordant treatment may improve clinical outcomes. Further improvements seem achievable by advocating for a \u201ccode ICH\u201d to streamline acute treatments. <\/jats:p>","DOI":"10.1159\/000536099","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T22:00:27Z","timestamp":1704924027000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Time for \u201cCode ICH\u201d? Workflow Metrics of Hyperacute Treatments and Outcome in Patients with Intracerebral Haemorrhage"],"prefix":"10.1159","author":[{"given":"Eva","family":"Bettschen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard M.","family":"Siepen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina B.","family":"Goeldlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madlaine","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Buecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Prange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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