{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:57:03Z","timestamp":1768816623851,"version":"3.49.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The aim was to evaluate the prognostic value of altered <i>Cyclin A2 (CCNA2)<\/i> gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. <b><i>Methods:<\/i><\/b> 62 patients who underwent surgical treatment for UTUC were included. Gene expression of <i>CCNA2<\/i>, <i>MKI67<\/i>, and <i>p53<\/i> was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of <i>CCNA2<\/i> expression with <i>MKI67<\/i> and <i>p53<\/i>. <b><i>Results:<\/i><\/b> The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high <i>CCNA2<\/i> expression levels showed longer OS (HR 0.33; 95% CI: 0.15\u20130.74; <i>p<\/i> = 0.0073). Multivariable Cox regression analyses identified <i>CCNA2<\/i> overexpression (HR 0.37; 95% CI: 0.16\u20130.85; <i>p<\/i> = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17\u20130.87; <i>p<\/i> = 0.0168) to be independent predictors for longer OS. <i>CCNA2<\/i> expression correlated positively with <i>MKI67<\/i> expression (Rho = 0.4376, <i>p<\/i> = 0.0005). <b><i>Conclusion:<\/i><\/b> Low <i>CCNA2<\/i> expression is significantly associated with worse OS. Thus, <i>CCNA2<\/i> might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores. <\/jats:p>","DOI":"10.1159\/000536184","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T22:00:30Z","timestamp":1705356030000},"page":"128-136","source":"Crossref","is-referenced-by-count":2,"title":["Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma"],"prefix":"10.1159","volume":"108","author":[{"given":"Margarete 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