{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:47:26Z","timestamp":1772452046527,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The traditional Japanese herbal medicine hochuekkito (TJ-41) has been reported to ameliorate systemic inflammation and malnutrition in patients with chronic obstructive pulmonary disease (COPD). TJ-41 has also been known to have preventive effects against influenza virus infection. However, its role in the acute exacerbation of COPD (AECOPD) remains to be elucidated. Our previous study established a murine model of viral infection-associated AECOPD that was induced by intratracheal administration of porcine pancreatic elastase (PPE) and polyinosinic-polycytidylic acid [poly(I:C)]. Here, we used this model and investigated the effects of TJ-41 in AECOPD. <b><i>Methods:<\/i><\/b> Specific pathogen-free C57BL\/6J mice were used. A COPD model was induced by treating mice intratracheally with PPE on day 0. To generate the murine model of AECOPD, poly(I:C) was administered intratracheally following PPE treatment on days 22\u201324. Mice were sacrificed and analyzed on day 25. Mice were fed a diet containing 2% TJ-41 or a control diet. <b><i>Results:<\/i><\/b> Daily oral intake of TJ-41 significantly decreased the numbers of neutrophils and lymphocytes in the bronchoalveolar lavage fluid (BALF), which was accompanied by decreased transcripts of CXC chemokines involved in neutrophil migration, viz., <i>Cxcl1<\/i> and <i>Cxcl2,<\/i> in whole lung homogenates and reduced Cxcl2 concentration in BALF. <b><i>Conclusion:<\/i><\/b> This study demonstrates the anti-inflammatory effects of TJ-41 in a mouse model of AECOPD, suggesting the effectiveness of TJ-41 for the management of COPD. Clinical investigations evaluating the therapeutic efficacy of TJ-41 in AECOPD would be meaningful. <\/jats:p>","DOI":"10.1159\/000536348","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T22:00:31Z","timestamp":1707775231000},"page":"121-126","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Inflammatory Effects of Japanese Herbal Medicine Hochuekkito in a Mouse Model of Acute Exacerbation of Chronic Obstructive Pulmonary Disease"],"prefix":"10.1159","volume":"109","author":[{"given":"Kensuke","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Hiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Isago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1819PP"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61382-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2022.100839"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6837"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000452474"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000485628"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000455918"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/all.14528"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S136592"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S42544"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.86"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0809532"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b20-00556"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00109906"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pha\/article-pdf\/109\/2\/121\/4190848\/000536348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pha\/article-pdf\/109\/2\/121\/4190848\/000536348.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:06:30Z","timestamp":1745424390000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,4,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000536348","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25206626","asserted-by":"subject"}]},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}