{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:22Z","timestamp":1785451282280,"version":"3.56.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Childhood obesity is a global health problem that is associated with various metabolic complications, such as insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. The mechanisms underlying the development of insulin resistance in childhood obesity are not fully understood. Nephroblastoma overexpressed gene (NOV), also known as CCN3, is a member of the CCN family of matricellular proteins that modulate cell proliferation, differentiation, adhesion, migration, and survival. Previous studies have shown that NOV\/CCN3 is involved in glucose metabolism and insulin signaling in various tissues and cell types. However, the role of NOV\/CCN3 in childhood obesity and insulin resistance remains unclear. <b><i>Methods:<\/i><\/b> In this study, we aimed to investigate the association between plasma NOV\/CCN3 levels and insulin resistance in 58 obese and 43 non-obese children aged 6\u201312 years. We measured plasma NOV\/CCN3 levels by enzyme-linked immunosorbent assay and assessed insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR). We also collected clinical and biochemical data, such as body mass index (BMI), waist circumference (WC), blood pressure (BP), fasting glucose (FG), fasting insulin (FI), lipid profile, and inflammatory markers. <b><i>Results:<\/i><\/b> We found that plasma NOV\/CCN3 levels were significantly higher in obese children than in non-obese children (<i>p<\/i> &lt; 0.001) and positively correlated with BMI (<i>r<\/i> = 0.42, <i>p<\/i> &lt; 0.001), WC (<i>r<\/i> = 0.38, <i>p<\/i> &lt; 0.001), BP (<i>r<\/i> = 0.35, <i>p<\/i> &lt; 0.001), FG (<i>r<\/i> = 0.31, <i>p<\/i> &lt; 0.001), FI (<i>r<\/i> = 0.45, <i>p<\/i> &lt; 0.001), HOMA-IR (<i>r<\/i> = 0.48, <i>p<\/i> &lt; 0.001), triglycerides (<i>r<\/i> = 0.28, <i>p<\/i> &lt; 0.001), low-density lipoprotein cholesterol (<i>r<\/i> = 0.26, <i>p<\/i> &lt; 0.001), and C-reactive protein (CRP) (<i>r<\/i> = 0.32, <i>p<\/i> &lt; 0.001). Multiple linear regression analysis revealed that plasma NOV\/CCN3 levels were independently associated with HOMA-IR after adjusting for age, sex, BMI, WC, BP, FG, FI, lipid profile, and CRP (\u03b2 = 0.36, <i>p<\/i> &lt; 0.001). <b><i>Conclusion:<\/i><\/b> These results suggest that plasma NOV\/CCN3 levels are elevated in childhood obesity and are associated with insulin resistance, indicating that NOV\/CCN3 may play a role in the pathogenesis of metabolic disorders in obese children. <\/jats:p>","DOI":"10.1159\/000536433","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T22:00:37Z","timestamp":1706911237000},"page":"196-201","source":"Crossref","is-referenced-by-count":2,"title":["A Comprehensive Study on the Association between Plasma NOV\/CCN3 Levels and Insulin Resistance in Childhood Obesity"],"prefix":"10.1159","volume":"80","author":[{"given":"Yuesheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32129-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S302"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.2.57"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.07.025"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203727200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404903200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.1.10-21.1992"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066788"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0617"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064957"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2022.2051045"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0617"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-023-06590-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193060"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29069"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nature05483"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/414799a"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/anm\/article-pdf\/80\/4\/196\/4262829\/000536433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/anm\/article-pdf\/80\/4\/196\/4262829\/000536433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:24Z","timestamp":1745424444000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2024,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000536433","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}