{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:17:28Z","timestamp":1779211048042,"version":"3.51.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> <i>Helicobacter pylori<\/i> eradication therapy may worsen gastroesophageal reflux disease that is a significant risk factor for Barrett\u2019s esophagus. However, the relationship between eradication therapy and Barrett\u2019s esophagus remains controversial. This study evaluated the impact of <i>Helicobacter pylori<\/i> eradication on the lengthening of Barrett\u2019s esophagus. <b><i>Materials and Methods:<\/i><\/b> We conducted a retrospective analysis of consecutive patients who successfully underwent <i>Helicobacter pylori<\/i> eradication between 2004 and 2017. Endoscopic images obtained before and after eradication therapy were compared for Barrett\u2019s esophagus length according to the Prague C&amp;M criteria and the presence of reflux esophagitis based on the Los Angeles classification. <b><i>Results:<\/i><\/b> A total of 340 patients were analyzed (mean age: 66.9 \u00b1 12.9 years) for a median follow-up of 55 months (interquartile range: 29.8\u201389.3). At the initial endoscopic assessment, 187 patients (55%) had a hiatal hernia, and all patients had gastric atrophy (C-0 to I: 2%, C-II to III: 47%, O-I to III: 51%). Reflux esophagitis was detected in 7 patients (2%) before eradication and in 21 patients (6%) afterward, which was a significant increase (<i>p<\/i> = 0.007). Barrett\u2019s esophagus was identified in 69 patients (20%) before eradication, with a median length of C0M1. Elongation after treatment was observed in only 2 patients (0.6%). We observed no significant increase in either the prevalence (<i>p<\/i> = 0.85) or the median length (<i>p<\/i> = 0.5) of Barrett\u2019s esophagus. <b><i>Conclusions:<\/i><\/b> Only 0.6% of patients exhibited Barrett\u2019s esophagus lengthening after <i>Helicobacter pylori<\/i> eradication therapy, suggesting no significant impact of the treatment on the development or elongation of Barrett\u2019s esophagus. <\/jats:p>","DOI":"10.1159\/000536443","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T22:00:32Z","timestamp":1706652032000},"page":"186-191","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between <i>Helicobacter pylori<\/i> Eradication and Barrett\u2019s Esophagus Elongation"],"prefix":"10.1159","volume":"105","author":[{"given":"Kenta","family":"Hashigami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Iwaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadanobu","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiro","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Akamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320839"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(97)70024-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.251"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01189.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.155"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13298"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12688"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01418-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000526154"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000519602"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000519922"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309220"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-018-0642-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.032"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00155.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211059942"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.11.042"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91510-b"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308552"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750813"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.9.1155"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330616"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/105\/3\/186\/4235364\/000536443.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/105\/3\/186\/4235364\/000536443.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:30Z","timestamp":1745424450000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,3]]},"published-print":{"date-parts":[[2024,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000536443","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25109426","asserted-by":"subject"}]},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}