{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:22:15Z","timestamp":1777980135275,"version":"3.51.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<b><i>Introduction:<\/i><\/b> Mutation in <i>Kristin ras sarcoma virus (KRAS)<\/i> oncogene is the main driver in pancreatic ductal adenocarcinoma (PDAC) and is present in nearly 90% of patients with PDAC. <i>Epidermal growth factor receptor<\/i> (<i>EGFR<\/i>) mutation is rare in PDAC and is mostly present in the absence of <i>KRAS<\/i> mutation. Co-occurrence of <i>KRAS<\/i> and <i>EGFR<\/i> mutations is extremely rare, and the value of EGFR inhibition in these cases is unknown. <b><i>Case Presentation:<\/i><\/b> Here, we present a case of metastatic PDAC with co-occurrence of <i>KRAS<\/i> G12V and <i>EGFR<\/i> L730R. Despite primary resistance to folinic acid, fluorouracil, irinotecan, oxaliplatin, and gemcitabine\/nab-paclitaxel, this patient had a biochemical response (decrease in carbohydrate antigen 19-9) and disease control of 7 months on gemcitabine\/erlotinib (an EGFR inhibitor). This outcome is remarkable in the late-line PDAC treatment setting and is unusual after the progression of the tumor on gemcitabine\/nab-paclitaxel chemotherapy. <b><i>Conclusion:<\/i><\/b> This case suggests that gemcitabine\/erlotinib could be an effective treatment in patients with PDAC and co-occurrence of <i>EGFR<\/i> and <i>KRAS<\/i> mutations. <\/jats:p>","DOI":"10.1159\/000536552","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T22:01:20Z","timestamp":1709330480000},"page":"399-406","source":"Crossref","is-referenced-by-count":5,"title":["Pancreatic Adenocarcinoma with Co-Occurrence of <i>KRAS<\/i> and <i>EGFR<\/i> Mutations: Case Report and Literature Review"],"prefix":"10.1159","volume":"17","author":[{"given":"Juhi","family":"Mody","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Kamgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2021.06.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.9525"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26797"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2021.100342"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_729_18"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4216"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.210"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103327"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7744"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2023.41.4_suppl.735"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804385"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110096"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1153"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102796"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-015-0158-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.08.005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070677"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903387"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6733"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-021-09990-2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.5007"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/399\/4175024\/000536552.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/399\/4175024\/000536552.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:17Z","timestamp":1745424497000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000536552","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25132427","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}