{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:30:52Z","timestamp":1790721052393,"version":"4.1.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies against extensive cardiovascular evaluations in identifying high-risk individuals among 35\u201350-year-old apparently healthy men. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We applied ACSM and ESC pre-participation screenings to 25 men participating in a study on first-time marathon running. We compared screening outcomes against medical history, physical examination, electrocardiography, blood tests, echocardiography, cardiopulmonary exercise testing, and magnetic resonance imaging. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; ACSM screening classified all participants as \u201cmedical clearance not necessary.\u201d ESC screening classified two participants as \u201chigh-risk.\u201d Extensive cardiovascular evaluations revealed \u22651 minor abnormality and\/or cardiovascular condition in 17 participants, including three subjects with mitral regurgitation and one with a small atrial septal defect. Eleven participants had dyslipidaemia, six had hypertension, and two had premature atherosclerosis. Ultimately, three (12%) subjects had a serious cardiovascular condition warranting sports restrictions: aortic aneurysm, hypertrophic cardiomyopathy (HCM), and myocardial fibrosis post-myocarditis. Of these three participants, only one had been identified as \u201chigh-risk\u201d by the ESC screening (for dyslipidaemia, not HCM) and none by the ACSM screening. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Numerous occult cardiovascular conditions are missed when applying current ACSM\/ESC screening strategies to apparently healthy middle-aged men engaging in their first high-intensity endurance sports event. <\/jats:p>","DOI":"10.1159\/000536553","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T22:00:30Z","timestamp":1710540030000},"page":"255-263","source":"Crossref","is-referenced-by-count":7,"title":["Pre-Participation Screenings Frequently Miss Occult Cardiovascular Conditions in Apparently Healthy Male Middle-Aged First-Time Marathon Runners"],"prefix":"10.1159","volume":"149","author":[{"given":"Inarota","family":"Laily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G.H.","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"van Steijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Bijsterveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianus J.","family":"Bakermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Froeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"van den Berg-Faay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand H.","family":"de Haan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne H.A.C.M.","family":"de Bruin-Bon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Nils","family":"Planken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald T.","family":"Jorstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3857"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.06.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.631237"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319852808"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.294"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041627"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa605"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2014-093857"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13457"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31826c5552"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001868"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-022-01708-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.07.007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2022-002060"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4158\/EP171764.APPGL"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-097331"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw180"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx532"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2016.04.005"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.609719"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2854"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.06.33"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.1042"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000937"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2022.08.006"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad152"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crd\/article-pdf\/149\/3\/255\/4235809\/000536553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/149\/3\/255\/4235809\/000536553.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:18Z","timestamp":1745424498000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000536553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,3]]},"published-print":{"date-parts":[[2024,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000536553","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}