{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:42:00Z","timestamp":1768030920939,"version":"3.49.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Endothelial dysfunction (ED) is considered a marker of vascular complications, especially in patients with end-stage kidney disease (ESKD). Inflammation and the uremic state contribute to ED in patients undergoing hemodialysis (HD). Recently, the medium cut-off (MCO) dialysis membrane has been proposed to efficiently remove inflammatory cytokines and large, middle-sized uremic toxins, with the potential effect to improve endothelial function. This study aimed to compare the effect of dialysis with MCO or high-flux membranes on the endothelial function of patients on chronic HD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A prospective, randomized, crossover study in which 32 patients with ESKD were dialyzed for 12 weeks with each membrane, including a 4-week washout period between treatments. Endothelial function was assessed by flow-mediated dilation (FMD) using brachial artery ultrasound at weeks 1, 12, 16, and 28. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The population consisted of 59% men, 52.7 \u00b1 13.4 years, 16% non-black, on HD for 8.8 (4.1\u201315.1) years, and 72% with arteriovenous fistula. Hypertension was the most common etiology of chronic kidney disease, and 34% of patients had previous cardiovascular disease. Patients were grouped, regardless of treatment sequence, into MCO or high-flux groups, since no carryover (&lt;i&gt;p&lt;\/i&gt; = 0.634) or sequence (&lt;i&gt;p&lt;\/i&gt; = 0.998) effects were observed in the FMD assessment. The ANOVA model with repeated measures showed no effects of treatment (&lt;i&gt;p&lt;\/i&gt; = 0.426), time (&lt;i&gt;p&lt;\/i&gt; = 0.972), or interaction (&lt;i&gt;p&lt;\/i&gt; = 0.413) in the comparison of FMD between the MCO and high-flux groups. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Dialysis performed with MCO, or high-flux membranes, had no influence on endothelial function in patients undergoing HD. However, a trend towards increased FMD was observed with the use of the MCO membrane. <\/jats:p>","DOI":"10.1159\/000537679","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T22:00:30Z","timestamp":1707429630000},"page":"565-573","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Hemodialysis with Medium Cut-Off versus High-Flux Membranes on Endothelial Function of Patients with Chronic Kidney Disease"],"prefix":"10.1159","volume":"53","author":[{"given":"Rachel Gatti","family":"Armani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aluizio Barbosa","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Vercia Rocha e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Verardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Bortolotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia F.","family":"Canziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139x.2003.16025.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000479250"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.15"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s85.25.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000417"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000093240.84097.fe"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000321750"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000369817"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010531"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222547"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800747"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.9.1002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.06.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_90"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.08.006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1741826711398179"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.2105"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01746-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2254"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11121251"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3081856"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.00925.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000468959"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0002-x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000489993"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000479262"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr081"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac095"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft448"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003440"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829760"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198320"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169024"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.774052"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1159\/000508061"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02562-3"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00380118"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0098-z"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143458"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/doi\/10.1159\/000537679\/4190644\/000537679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/doi\/10.1159\/000537679\/4190644\/000537679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:05:09Z","timestamp":1745420709000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,11]]},"published-print":{"date-parts":[[2024,7,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000537679","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}