{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:11Z","timestamp":1745468591173,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"abstract":"<jats:p>Introduction: The role of curcuminoids, a striking antioxidant, in prevention of contrast-induced acute kidney injury (CI-AKI) remains unknown. We aim to evaluate the efficacy and safety of curcuminoids in preventing CI-AKI in patients undergoing elective coronary angiography (CAG) and\/or percutaneous coronary intervention (PCI). \nMethods: We randomized 114 patients who were undergoing elective CAG and\/or PCI to receive curcuminoids, 4 grams\/day (1 day before, and 1 day after the procedure, n=56) or placebo (n=58). Serum creatinine was assessed at baseline, 12, 24 and 48 hours after contrast exposure. The primary endpoint was development of CI-AKI defined as serum creatinine increase \u22650.3 mg\/dL within 48 hours after contrast exposure. The secondary endpoint was the occurrence of kidney injury defined by &gt;30% increase in urine neutrophil gelatinase-associated lipocalin (NGAL). \nResults: Baseline characteristics were comparable between the two groups. Seven (12.7%) in curcuminoids group and eight (14.0%) in placebo group developed CI-AKI (p=0.84). The incidence of increased urine NGAL was comparable in the placebo and curcuminoids groups (39.6% vs. 50%, respectively; p=0.34). None in both groups had drug-related adverse events. \nConclusion: This is a pilot study to demonstrate the safety and tolerability of curcuminoids in patients undergoing elective CAG and\/or PCI. Curcuminoids have no protective effects against kidney injury after elective CAG and\/or PCI.<\/jats:p>","DOI":"10.1159\/000537710","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T22:00:45Z","timestamp":1707861645000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of curcuminoids on contrast-induced acute kidney injury after elective coronary angiography or intervention: A pilot randomized, double-blind, placebo-controlled study"],"prefix":"10.1159","author":[{"given":"Kajohnsak","family":"Noppakun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janjira","family":"Jitraknatee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuttitham","family":"Suteeka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chidchanok","family":"Ruengorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surapon","family":"Nochaiwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Gunaparn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanwarang","family":"Wongcharoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,2,13]]},"container-title":["Cardiorenal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crm\/article-pdf\/doi\/10.1159\/000537710\/4168398\/000537710.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crm\/article-pdf\/doi\/10.1159\/000537710\/4168398\/000537710.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:05:37Z","timestamp":1745420737000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000537710","archive":["Portico"],"relation":{},"ISSN":["1664-3828","1664-5502"],"issn-type":[{"type":"print","value":"1664-3828"},{"type":"electronic","value":"1664-5502"}],"subject":[],"published":{"date-parts":[[2024,2,13]]}}}