{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:41:51Z","timestamp":1778902911142,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; This study is a case of solitary clear cell renal cell carcinoma (ccRCC) eyelid metastasis in a 66-year-old man as the first sign of a primary tumor. ccRCC usually spreads to the lungs, mediastinum, bones, liver, and brain, while ocular metastases are rare. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; Solitary metastasis presented as a solid mass in the central third of the upper eyelid, which has been growing for 3 weeks. Treatment included tumor removal and blepharoplasty. Histopathological examination showed metastasis of clear cell renal carcinoma. A thorough examination revealed a primary tumor on the lower pole of the right kidney. A right nephrectomy was performed, and histopathology showed ccRCC. Postoperative examinations showed no signs of local or systemic disease. Sunitinib malate was administered to the patient. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The eyelid metastasis in this case was still solitary and had been discovered before the existence of the primary tumor was known. Ocular metastasis of renal carcinoma is a rare initial manifestation of the disease and therefore requires a multidisciplinary approach in the treatment of these patients. <\/jats:p>","DOI":"10.1159\/000537860","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T22:00:33Z","timestamp":1710885633000},"page":"477-483","source":"Crossref","is-referenced-by-count":1,"title":["Solitary Clear Cell Renal Cell Carcinoma Metastasis to the Eyelid: A Case Report"],"prefix":"10.1159","volume":"17","author":[{"given":"Ognjen","family":"Zrin\u0161\u0107ak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Kasumovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Krolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Ivekovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Malenica Ravli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Toma\u0161kovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Vatavuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(81)34854-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/cren.2020.0107"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702645"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.120"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.11.035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oftal.2016.11.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.01.039"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02004.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000236211.90803.96"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282f9782b"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065044"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000886"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.21.2516"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.07.022"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2328"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01159-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-022-00676-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0069"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/477\/4180963\/000537860.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/477\/4180963\/000537860.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:07:03Z","timestamp":1745420823000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000537860","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25226168","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]}}}