{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:54:19Z","timestamp":1787320459819,"version":"build-2736575974"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<b><i>Introduction:<\/i><\/b> The presence of three different entities in a single patient is usually of clinical interest and mostly anecdotal. The overlap of systemic sclerosis (SSc), Sj\u00f6gren syndrome (SS), and ANCA-associated renal-limited vasculitis has been reported only once previously. <b><i>Case Presentation:<\/i><\/b> A 61-year-old female was evaluated at consultation with 2 years of symptomatology, presenting cardboard-like skin, sclerodactyly, limited oral opening, and dry skin and eyes. She was admitted for progressive renal failure (serum creatinine, 5.5 mg\/dL). Her serology work-up showed positive anti-SCL-70, anti-Ro, anti-La, anti-MPO, and antinuclear antibodies. Renal biopsy was performed and confirmed histological findings for SSc, SS, and ANCA-associated vasculitis with active extracapillary glomerulonephritis with fibrous predominance (EUVAS-Berden sclerotic class), active tubulointerstitial nephritis, focal tubular injury, and moderate chronic arteriolopathy. Treatment with 6 monthly doses of methylprednisolone and cyclophosphamide was established. At the last follow-up, the patient maintained a stable serum creatinine level of 2.6 mg\/dL and had decreased proteinuria, no erythrocyturia, and no requirement for renal replacement therapy. <b><i>Conclusion:<\/i><\/b> Systemic sclerosis is a rare autoimmune disease; nevertheless, overlap with Sj\u00f6gren syndrome is relatively common, although its association with ANCA vasculitis is anecdotal. Diagnostic integration presents a challenge for nephrologists to define the prognosis and a specific treatment.<\/jats:p>","DOI":"10.1159\/000537873","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T18:00:35Z","timestamp":1711130435000},"page":"48-55","source":"Crossref","is-referenced-by-count":1,"title":["Overlap Syndrome of Diffuse Systemic Sclerosis, Sj\u00f6gren Syndrome, and ANCA-Associated Renal-Limited Vasculitis: Three Entities in One Patient \u2013 Case Report"],"prefix":"10.1159","volume":"14","author":[{"given":"Angela Maria","family":"Cordoba-Hurtado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fuentes-Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Monserrat","family":"Perez-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilia","family":"Soto-Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Valdez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.11.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S221471"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.124"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1839-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.04.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.174"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000381946"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803537"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-10-200905190-00004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310311"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31827781fd"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/385938"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283588dcf"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101248"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/art.21922"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cnd\/article-pdf\/14\/1\/48\/4182295\/000537873.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cnd\/article-pdf\/14\/1\/48\/4182295\/000537873.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:07:11Z","timestamp":1745406431000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000537873","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25272547","asserted-by":"subject"}]},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]}}}