{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:29Z","timestamp":1787017949001,"version":"build-2736575974"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterization (UVC), but risk factors remain unclear. This study aims to analyze the variables associated to PVT in near- to full-term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This is retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1,500 g. All infants were assessed for UVC location and PVT using ultrasonography performed between day 5 and day 10 after catheterization. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 213 eligible patients, PVT was diagnosed in 57 (27%); among them, 54 (95%) were localized in the left portal vein branch. With all significant factors in univariate analysis considered, higher gestational age at birth (adjusted OR 1.35; 95% CI: 1.12\u20131.64, &lt;i&gt;p&lt;\/i&gt; = 0.002) and duration of UVC placement (adjusted OR 1.36; 95% CI: 1.11\u20131.67, &lt;i&gt;p&lt;\/i&gt; = 0.004) were the main risk factors of PVT. Among 87 infants who were cooled for HIE, 31 (36%) had PVT compared to 26 (21%) in infants without CTH. Using a multivariate model including variables linked to treatment procedures only, an increased PVT incidence was statistically associated with UVC duration (adjusted OR 1.33; 95% CI: 1.08; 1.63, &lt;i&gt;p&lt;\/i&gt; = 0.01) and CTH (adjusted OR 1.94; 95% CI: 1.04\u20133.65, &lt;i&gt;p&lt;\/i&gt; = 0.04). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Left PVT was frequently observed in near- to full-term neonates with UVC. Among factors linked to treatment procedures, both duration of UVC and CTH exposure for HIE were found to be independent risk factors of PVT.<\/jats:p>","DOI":"10.1159\/000537902","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T18:00:32Z","timestamp":1711130432000},"page":"478-484","source":"Crossref","is-referenced-by-count":5,"title":["Association between Portal Vein Thrombosis after Umbilical Vein Catheterization and Neonatal Asphyxia"],"prefix":"10.1159","volume":"121","author":[{"given":"Marina","family":"Colella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemis","family":"Toumazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Bourmaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Boizeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guilmin-Crepon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Leick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophea","family":"Khat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Alison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Baud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Biran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.96.5.939"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0678-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02349.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.01.051"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.08.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.3.r01jn17645"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.07.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211786"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0132-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.05.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316762"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.09.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2009.10.030"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0929-693x(03)00163-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306213"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27572"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1999.355392.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328364f9b0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1179\/027249309X12547917868961"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001052"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.11.026"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.774705"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/478\/4264238\/000537902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/478\/4264238\/000537902.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:07:32Z","timestamp":1745406452000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000537902","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3248859\/v1","asserted-by":"object"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}