{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:10:46Z","timestamp":1780614646340,"version":"3.54.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The objective of this study was to determine the sensitivity of brain magnetic resonance imaging (MRI) in the detection of choroidal metastasis (CM) from systemic primary cancers. <b><i>Methods:<\/i><\/b> A retrospective chart review identified patients with clinically confirmed CM seen on the Oncology Service (Byers Eye Institute) between January 2018 and March 2022. Patients had an MRI brain and\/or orbits performed within 3 months of CM diagnosis. Evaluation of CM detection by MRI was then divided into two parts: an initial \u201cstandard read,\u201d where determination of CM detection was based solely on the original radiology report, to reflect real-world performance, and a subsequent \u201cdedicated read,\u201d for which a board-certified neuroradiologist, blinded to the laterality and location of the CM, reevaluated the studies to provide an objective \u201cgold standard\u201d interpretation regarding the radiographic detection of CM. <b><i>Results:<\/i><\/b> The study included 42 eyes of 40 patients with confirmed CM. On standard read, MRI detection of CM occurred in 21 of 42 eyes (50%), with no significant difference between MRI brain and orbit protocols (<i>p =<\/i> 0.249). Features associated with improved detection were increased tumor basal diameter (<i>p<\/i> &lt; 0.001) and ultrasonographic tumor thickness (<i>p<\/i> = 0.003). On dedicated read, MRI detection of CM improved to 26 of 33 eyes (76%; limited to eyes with full complement of pre- and post-gadolinium sequences). Post-gadolinium 3D fluid-attenuated inversion recovery (FLAIR) sequence with fat suppression was the most sensitive (88%) for CM detection. 42% and 58% of lesions were visualized using conventional pre-gadolinium T1- and T2-weighted imaging, respectively. <b><i>Conclusions:<\/i><\/b> MRI sensitivity to detect CM improved from 50% to 76% with focused reinterpretation. Increased utilization of the post-gadolinium 3D FLAIR sequence and increased ocular scrutiny in cancer patients undergoing brain imaging may facilitate earlier diagnosis of CM. <\/jats:p>","DOI":"10.1159\/000537949","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T22:00:35Z","timestamp":1708466435000},"page":"80-87","source":"Crossref","is-referenced-by-count":3,"title":["Sensitivity of Magnetic Resonance Imaging in Detection of Choroidal Metastases"],"prefix":"10.1159","volume":"10","author":[{"given":"Michael D.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashem","family":"Ghoraba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E.","family":"Sabage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Fischbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithvi","family":"Mruthyunjaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.252"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000480640"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(97)30148-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700535"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.099416"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811161-1.00007-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2015.03.040"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23740"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s003300100936"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.09.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.156.3.4023227"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.014"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(03)00192-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303519"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.10.1159"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/oop\/article-pdf\/10\/2\/80\/4242093\/000537949.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/oop\/article-pdf\/10\/2\/80\/4242093\/000537949.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:08:07Z","timestamp":1745420887000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000537949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,14]]},"published-print":{"date-parts":[[2024,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000537949","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}