{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:11:41Z","timestamp":1784308301464,"version":"3.55.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> <i>Aspergillus fumigatus<\/i> is the most common airborne allergen of the <i>Aspergillus<\/i> family. However, allergies to <i>Aspergillus<\/i> spp. are increasing, and subsequently, allergies to <i>Aspergillus<\/i> species other than <i>fumigatus<\/i> are also on the rise. Commercial diagnostic tools are still limited to <i>Aspergillus fumigatus<\/i>. Hence, there is a need for improved tests. We decided to investigate the correlation between serological sensitization to <i>A. fumigatus<\/i> and other <i>Aspergillus<\/i> species. <b><i>Methods:<\/i><\/b> Hundred and seven patients with positive skin prick tests to <i>A. fumigatus<\/i> were included in this study. Immunoglobulin E (IgE) concentrations against <i>A. fumigatus<\/i>, <i>A. terreus<\/i>, <i>A. niger<\/i>, <i>A. flavus<\/i>, and <i>A. versicolor<\/i> were measured from specimens by fluorescent enzyme-linked immunoassays. <b><i>Results:<\/i><\/b> Patients showed considerably higher IgE concentrations against <i>A. fumigatus<\/i> (6.00 \u00b1 15.05 kUA\/L) than <i>A. versicolor<\/i> (0.30 \u00b1 1.01 kUA\/L), <i>A. niger<\/i> (0.62 \u00b1 1.59 kUA\/L), <i>A. terreus<\/i> (0.45 \u00b1 1.12 kUA\/L), or <i>A. flavus<\/i> (0.41 \u00b1 0.97 kUA\/L). Regression analysis yielded weak positive correlations for all <i>Aspergillus<\/i> spp., but low <i>r<\/i><sup>2<\/sup> values and heteroscedastic distribution indicate an overall poor fit of the calculated models. <b><i>Conclusion:<\/i><\/b> Serological sensitization against <i>A. fumigatus<\/i> does not correlate with sensitization against other <i>Aspergillus<\/i> spp. To detect sensitization against these, other diagnostic tools like a skin prick test solution of different <i>Aspergillus<\/i> spp. are needed. <\/jats:p>","DOI":"10.1159\/000538082","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T22:00:43Z","timestamp":1711576843000},"page":"767-774","source":"Crossref","is-referenced-by-count":2,"title":["Serological Cross-Reactivity of Various <i>Aspergillus<\/i> spp. with <i>Aspergillus fumigatus<\/i>: A Diagnostic Blind 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