{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:04:58Z","timestamp":1791813898292,"version":"4.3.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> End-tidal CO<sub>2<\/sub> (ETCO<sub>2<\/sub>) detector is currently recommended for confirmation of endotracheal tube placement during neonatal resuscitation. Whether it is feasible to use ETCO<sub>2<\/sub> detectors during mask ventilation to reduce risk of bradycardia and desaturations, which are associated with increased risk of death in preterm babies, is unknown. <b><i>Methods:<\/i><\/b> This is a pilot randomized controlled trial (NCT04287907) involving newborns 24 + 0\/7 to 32 + 0\/7 weeks gestation who required mask ventilation at birth. Infants were randomized into groups with or without colorimetric ETCO<sub>2<\/sub> detectors. Combined duration of any bradycardia (&lt;100 bpm) and time below prespecified target oxygen saturation (SpO<sub>2<\/sub>) as measured by pulse oximetry were compared. <b><i>Results:<\/i><\/b> Fifty participants were randomized, 47 with outcomes analysed (2 incomplete data, 1 postnatal diagnosis of trachea-oesophageal fistula). Mean gestational age and birthweight were 28.5 \u00b1 1.9 versus 29.4 \u00b1 1.6 weeks (<i>p<\/i> = 0.1) and 1,252.7 \u00b1 409.7 g versus 1,334.6 \u00b1 369.1 g (<i>p<\/i> = 0.5) in the intervention and control arm, respectively. Mean combined duration of bradycardia and desaturation was 276.7 \u00b1 197.7 s (intervention) and 322.7 \u00b1 277.7 s (control) (<i>p<\/i> = 0.6). Proportion of participants with any bradycardia or desaturation at 5 min were 38.1% (intervention) and 56.5% (control) (<i>p<\/i> = 0.2). No chest compressions, epinephrine administration, or death occurred in the delivery room. <b><i>Conclusion:<\/i><\/b> This pilot study demonstrates the feasibility of a trial to evaluate colorimetric ETCO<sub>2<\/sub> detectors during mask ventilation of very preterm infants to reduce bradycardia and low SpO<sub>2<\/sub>. Further assessment with a larger population will be required to determine if ETCO<sub>2<\/sub> detector usage at resuscitation reduces risk of adverse outcomes, including death and disability, in very preterm infants. <\/jats:p>","DOI":"10.1159\/000538083","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T22:00:43Z","timestamp":1711576843000},"page":"494-502","source":"Crossref","is-referenced-by-count":2,"title":["Colorimetric CO<sub>2<\/sub> Detector to Improve Effective Mask Ventilations in Very Preterm Infants: A Pilot Randomized Controlled Study"],"prefix":"10.1159","volume":"121","author":[{"given":"Juin Yee","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin Huey","family":"Quek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis S.E.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehena","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Y.V.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Samuel","family":"Rajadurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Thai","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305704"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-312366"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.08.023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2019-000592"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000276"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001179"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000322009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.10.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2493"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0560"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-325698"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2021110"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200136"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2057-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12868"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1452"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000530257"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.08.027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.07.012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.resplu.2022.100327"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16559"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.082008"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/494\/4264248\/000538083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/4\/494\/4264248\/000538083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:09:52Z","timestamp":1745420992000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000538083","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25303444","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}