{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:58:06Z","timestamp":1770469086647,"version":"3.49.0"},"reference-count":9,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<b><i>Introduction:<\/i><\/b> Atrial fibrillation or flutter (AF) is a well-known risk factor for ischemic stroke. While female sex has been associated with higher stroke risk among AF patients, overall sex-specific real-world burdens of AF-related strokes and hemorrhages are unknown. <b><i>Methods:<\/i><\/b> The 2016\u20132020 National Inpatient Sample was queried for hospitalizations, morbidity, and mortality due to AF-related ischemic strokes and bleeds. Patient demographic information, vascular risk factors, comorbidities, and stroke characteristics were extracted using ICD-10 codes. Overall incidences were calculated using total population estimates provided by the US Census Bureau, and relative risk was calculated by comparing annual incidences between men and women. <b><i>Results:<\/i><\/b> 2,420,870 ischemic stroke hospitalizations were identified; 542,635 (22.4%) were associated with AF. Overall, women had similar risk of hospitalization due to AF-related ischemic strokes compared to men; however, women had a higher risk of morbidity and mortality (RR 1.13 and 1.17, respectively; both <i>p<\/i> &lt; 0.001). In contrast, women had lower incidences of hospitalization, morbidity, and mortality due to AF-related bleeds (RR 0.82, 0.94, and 0.74, respectively; all <i>p<\/i> &lt; 0.001). Among patients with AF-related ischemic strokes, women had lower rates of anticoagulation use, higher rates of large vessel occlusion, and higher stroke severity (all <i>p<\/i> &lt; 0.001). These trends persisted among patients 80 years or older (all <i>p<\/i> &lt; 0.001). <b><i>Conclusion:<\/i><\/b> Women in the USA have higher incidences of morbidity and mortality from AF-related ischemic strokes than men. Future studies should investigate strategies to reduce morbidity and mortality due to AF-related strokes in women. <\/jats:p>","DOI":"10.1159\/000538108","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T22:00:30Z","timestamp":1709589630000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Sex Discrepancies in the Population Incidence of Stroke and Hemorrhage Related to Atrial Fibrillation or Flutter"],"prefix":"10.1159","author":[{"given":"Mihir","family":"Khunte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Colasurdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seemant","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.06.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4369"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2022.03.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018418"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.015689"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000492820"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.028"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23284"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ced\/article-pdf\/doi\/10.1159\/000538108\/4189237\/000538108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ced\/article-pdf\/doi\/10.1159\/000538108\/4189237\/000538108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:10:02Z","timestamp":1745421002000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":9,"URL":"https:\/\/doi.org\/10.1159\/000538108","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25329952","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,2]]}}}