{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:36:39Z","timestamp":1793723799094,"version":"4.6.1"},"reference-count":53,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; We comprehensively evaluated how self- and informant-reported neuropsychiatric symptoms (NPS) were differentially associated with cerebral amyloid-beta (A\u03b2) PET levels in older adults without dementia. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Two hundred and twenty-one participants (48% female, age = 73.4 years \u00b1 8.4, Clinical Dementia Rating = 0 [&lt;i&gt;n&lt;\/i&gt; = 184] or 0.5 [&lt;i&gt;n&lt;\/i&gt; = 37]) underwent an A\u03b2-PET scan (florbetapir or PIB), comprehensive neuropsychological testing, and self-reported (Geriatric Depression Scale \u2013 30 item [GDS-30]) and informant-reported interview (Neuropsychiatric Inventory Questionnaire [NPI-Q]) of NPS. Cerebral A\u03b2 burden was quantified using centiloids (CL). NPI-Q and GDS-30 queried the presence of NPS within 4 subdomains and 6 subscales, respectively. Regression models examined the relationship between NPS and A\u03b2-PET CL. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both higher self- and informant-reported NPS were associated with higher A\u03b2 burden. Among specific NPI-Q subdomains, informant-reported changes in depression, anxiety, and irritability were all associated with higher A\u03b2-PET. Similarly, self-reported (GDS-30) subscales of depression, apathy, anxiety, and cognitive concern were associated with higher A\u03b2-PET. When simultaneously entered, only self-reported cognitive concern was associated with A\u03b2-PET in the GDS-30 model, while both informant-reported anxiety and depression were associated with A\u03b2-PET in the NPI-Q model. Clinical status moderated the association between self-reported NPS and A\u03b2-PET such that the positive relationship between self-perceived NPS and A\u03b2 burden strengthened with increasing functional difficulties. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In a cohort of older adults without dementia, both self- and informant-reported measures of global NPS, particularly patient-reported cognitive concerns and informant-reported anxiety and depression, corresponded with cerebral A\u03b2 burden. NPS may appear early in the prodromal disease state and relate to initial AD proteinopathy burden, a relationship further exaggerated in those with greater clinical severity. <\/jats:p>","DOI":"10.1159\/000538376","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T21:00:26Z","timestamp":1714078826000},"page":"119-127","source":"Crossref","is-referenced-by-count":5,"title":["Neuropsychiatric Profiles and Cerebral Amyloid Burden in Adults without Dementia"],"prefix":"10.1159","volume":"53","author":[{"given":"Eva Q.","family":"Gontrum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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