{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:12:11Z","timestamp":1758359531274,"version":"3.44.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>&lt;p&gt;Introduction: Paediatric brain tumours in the sellar-suprasellar region are often associated with arginine vasopressin peptide deficiency (AVPD), either at diagnosis caused by the tumour itself or during follow-up as a consequence of treatments. The purpose of this research was to retrospectively describe the neuroradiological characteristics and the timing of AVPD development in a cohort of paediatric patients with craniopharyngioma (CP) or germ cell tumours (GCTs). Methods: We evaluated brain MRI at tumour diagnosis and at the onset of AVPD, as well as recorded clinical, endocrinological, and histopathological data, treatments, and outcome. Results: Seventy-two patients with AVPD were included: 46 CPs (M:F = 25:21) and 26 GCTs (M:F = 18:8). CPs were suprasellar (63%), sellar (4%), or both (33%). GCTs were suprasellar (65%), pineal (24%), or bifocal (11%). No statistically significant differences were noted in tumour size between CP and GCT. Posterior pituitary bright spot absence was reported at diagnosis or at follow-up (as surgery consequence) in all patients with AVPD, indicating that the absence of hyper-intensity is a cardinal feature of AVPD. When measurable, pituitary stalk was thickened in most GCT patients (61.5%). At AVPD diagnosis in GCT, the mean age was 11.9 years; 18 (69%) patients had AVPD at the time of tumour diagnosis, 5 (19.3%) before the diagnosis with a latency of 24.4 months (range 4\u201348), and 3 (11.5%) during follow-up (mean 24 months, range 4\u201360) due to tumour recurrence. GCT patients presented with severe endocrinological manifestations (18\/26), headache and vomiting (10\/26), visual impairment (5\/26), and behavioural changes with fatigue (1\/26). In CP, the mean age at AVPD diagnosis was 10.3 years; 7 (15.2%) patients had AVPD at time of tumour diagnosis, 37 (80.5%) developed it shortly after neurosurgery, and 2 patients (4.3%) after 2 and 4 months from surgery, respectively. Clinically, headache and visual abnormalities were the most frequent clinical symptoms at diagnosis of CP (39\/46, 84.8%), with hydrocephalus (16\/46, 35%) and displacement of optic chiasm (29\/46, 63%) at the initial MRI. While the vast majority of CP patients (93%) received only surgery, all GCT patients received radiation therapy in addition to or instead of surgery. Conclusion: An early differential diagnosis in children with AVPD and brain tumours is supported by a good understanding of the clinical features and imaging findings. Expert follow-up is necessary. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000538387","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T17:00:38Z","timestamp":1712941238000},"page":"266-273","source":"Crossref","is-referenced-by-count":0,"title":["Arginine Vasopressin Deficiency in Children with Craniopharyngioma and Cerebral Germ Cell Tumour: Two Sides of the Same Coin \u2013 Clinical and Radiological Features"],"prefix":"10.1159","volume":"98","author":[{"given":"Sabrina","family":"Criscuolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Partenope","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Tortora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ved Bhushan","family":"Arya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000336333"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031608"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010053431403"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1981"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101440"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00162-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1287"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2005.18.7.653"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.06.019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03121-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2817"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2015-0099"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0174"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092621"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab252"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0125-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov187"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30168"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.868558"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000262537"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-001-0752-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588516"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.2.0155"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-0413-8"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/doi\/10.1159\/000538387\/4212672\/000538387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000538387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:03:50Z","timestamp":1758297830000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000538387","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2024,3,15]]}}}