{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:29:56Z","timestamp":1768775396973,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The ghrelin system, which generates the appetite hormone, is harmed by obesity, a problem of worldwide public health. An efficient way to cure obesity is through bariatric surgery. This randomized controlled study\u2019s objective was to assess preoperative diet-related DNA methylation of <i>Ghrelin (GHRL)<\/i> levels in patients undergoing bariatric surgery. <b><i>Methods:<\/i><\/b> The 50 patients who volunteered to participate in the trial were randomly divided into two groups. The study group followed the very low-calorie diet for 2 weeks. The control group did not follow any diet. The physiological parameters, weight, and DNA methylation levels of the patients were assessed. <b><i>Results:<\/i><\/b> The percentage of excess weight loss (EWL) in the control and study groups was determined as 47.1% and 51.5%, respectively. The study group\u2019s <i>GHRL<\/i> percentage of methylated reference was 76.8%, whereas the control group\u2019s was 67.3%. It was concluded that the EWL and <i>GHRL<\/i> gene DNA methylation of the diet-treated study group were significantly higher than the control group (<i>p<\/i> &lt; 0.05). <b><i>Conclusion:<\/i><\/b> According to the findings, the pre-op diet had a favorable effect on the patient\u2019s behavior modification. It has also been shown to increase postoperative weight loss and DNA methylation of the <i>Ghrelin<\/i> gene. The ghrelin gene has been muted by methylation, making hunger regulation more manageable. <\/jats:p>","DOI":"10.1159\/000538406","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T22:00:33Z","timestamp":1710885633000},"page":"153-160","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Diet before Bariatric Surgery on Ghrelin Level through DNA Methylation"],"prefix":"10.1159","volume":"80","author":[{"given":"Duygu","family":"G\u00fc\u00e7l\u00fc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilg\u00fcn","family":"I\u015f\u0131ksa\u00e7an","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Seyit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuman","family":"Gedikba\u015f\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130rem","family":"Erdil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamay Seda","family":"Ta\u015f\u00e7\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref1"},{"key":"ref2"},{"key":"ref3"},{"key":"ref4"},{"key":"ref5"},{"key":"ref6"},{"key":"ref7"},{"key":"ref8"},{"key":"ref9"},{"key":"ref10"},{"key":"ref11"},{"key":"ref12"},{"key":"ref13"},{"key":"ref14"},{"key":"ref15"},{"key":"ref16"},{"key":"ref17"},{"key":"ref18"},{"key":"ref19"},{"key":"ref20"},{"key":"ref21"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/anm\/article-pdf\/80\/3\/153\/4237122\/000538406.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/anm\/article-pdf\/80\/3\/153\/4237122\/000538406.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:12:30Z","timestamp":1745421150000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,4]]},"published-print":{"date-parts":[[2024,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000538406","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}