{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:12:40Z","timestamp":1791216760033,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Although programmed death ligand 1 (PD-L1) inhibitor plus chemotherapy regimen is a promising strategy for malignant tumors, it can induce significant immune-related adverse events, such as immune-related pneumonitis. Here, we report the first case of lethal immune-related pneumonitis in an Asian patient receiving anti-PD-L1 treatment. Case Presentation: A 68-year-old man was diagnosed with small cell lung cancer and interstitial pneumonia. After his pulmonary infection was relieved by comprehensive treatment, the patient received first-line treatment with durvalumab plus etoposide and carboplatin. Two weeks after starting durvalumab treatment, the patient had chest pain and shortness of breath. He was diagnosed with immune-induced pneumonia and treated with methylprednisolone, cefoperazone, and sulbactam, followed by oxygen and pirfenidone. Oxygen partial pressure decreased to 58 mm Hg within next the 4 days and laboratory assessment suggested cytokine storm. The patient underwent 2 plasma exchanges, one double filtration plasmapheresis and oxygen saturation decreased continuously. The patient died 1 month after durvalumab treatment. Conclusion: Immune-related pneumonitis induced by PD-L1 inhibitors is rare but life-threatening. Infection should be ruled out before starting immunotherapy. <\/jats:p>","DOI":"10.1159\/000538429","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T08:24:58Z","timestamp":1724747098000},"page":"673-680","source":"Crossref","is-referenced-by-count":2,"title":["Lethal Immune-Related Pneumonitis after Durvalumab Therapy for Small Cell Lung Cancer: A First Case in China"],"prefix":"10.1159","volume":"17","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojie","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14842"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.10.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0058"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01159-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103596"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw141"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.02.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S136818"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001731"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmer.2022.100969"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-1792"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709937"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2017.12.10"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1202ST"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1134"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32222-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016158"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0047"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/673\/4244191\/000538429.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/17\/1\/673\/4244191\/000538429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:12:51Z","timestamp":1745421171000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,6,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000538429","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25563321","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]}}}