{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:24:29Z","timestamp":1790749469280,"version":"4.1.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The association between food protein-induced enterocolitis syndrome (FPIES) and wheat ingestion in children with celiac disease is unknown at this time. <b><i>Methods:<\/i><\/b> We present seven cases of children with celiac disease who presented with symptoms of wheat-triggered acute FPIES (a-FPIES). An oral food challenge (OFC) with wheat allergen followed by 4 h of observation was performed. Activation of innate system cells was measured at baseline (T0), during symptoms (Ts), and 4 h after symptom onset (Ts + 4). A panel of human inflammatory cytokines was also performed. <b><i>Results:<\/i><\/b> All patients reacted to the first allergen dose. Three patients experienced a decrease of 30 mm Hg in systolic blood pressure and tachycardia and required hemodynamic resuscitation. Neutrophilia and a decrease in eosinophil count were evident at 4 h after symptom onset. At 4 h after symptom onset, cytokines (IL-6 and IL-8, and to a lesser degree, IL-10) were elevated. <b><i>Conclusion:<\/i><\/b> In a small sample of celiac patients with wheat exposure in an OFC, symptoms and acute immunological changes in serum inflammatory cytokine profile were consistent with a-FPIES. <\/jats:p>","DOI":"10.1159\/000538500","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T21:00:30Z","timestamp":1713819630000},"page":"865-870","source":"Crossref","is-referenced-by-count":4,"title":["Wheat-Triggered Food Protein-Induced Enterocolitis Syndrome in Celiac Children on Gluten-Free Diet: A New Clinical Association"],"prefix":"10.1159","volume":"185","author":[{"given":"Margarita","family":"Giraldo-Tugores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Camarero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garbi\u00f1e","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"De Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s David","family":"Espejo-Mambi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Terrados-Cepeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"de la Hoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.966"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.044"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.971"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1163765"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112293"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61270-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04597.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02934-w"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/9\/865\/4273470\/000538500.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/9\/865\/4273470\/000538500.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:13:24Z","timestamp":1745421204000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,2]]},"published-print":{"date-parts":[[2024,9,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000538500","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25471780","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}